口服阿托品对腮腺肿瘤术后伤口愈合的影响

Effects of Oral Administration of Atropine on Wound Healing after Parotid Tumor Resection

为探究口服阿托品对腮腺肿瘤术后伤口愈合的影响,本研究选取在重庆市九龙坡区人民医院进行腮腺肿瘤切除术患者80例,样本收集时间区间为2016年2月至2017年9月,采用随机数字表法将患者随机分为观察组(n=42)和对照组(n=38),两组均进行区域性切除手术,其中观察组在手术后给予口服阿托品和加压包扎处理,对照组在手术后仅给予加压包扎处理,处理后观察两组术后涎瘘等并发症的发生情况。研究结果发现,观察组术后涎瘘发生率为4.76%,明显低于对照组的23.68%,两组差异比较有统计学意义(p<0.05);观察组术后涎瘘分级明显低于对照组(p<0.05);观察组术后平均包扎时间为(10.48±1.30)d,明显短于对照组(14.50±1.56)d的平均包扎时间,差异比较有统计学意义(p<0.05);观察组和对照组术后耳周皮肤麻木和Frey综合征,差异比较无统计学意义(p>0.05)。研究表明,腮腺肿瘤切除手术后,口服阿托品,可促进伤口愈合,减少术后涎瘘的发生,缩短加压包扎时间,具有较好的临床应用价值。

To investigate the effect of oral administration of atropine on wound healing after parotid tumor surgery, in this study, 80 patients undergoing parotid tumor resection in Chongqing Jiulongpo People's Hospital were selected. Samples were collected from February 2016 to September 2017. The patients were randomly divided into observation group (n=42) and control group (n=38) by random number table method. The two groups underwent regional resection. The observation group was treated with oral administration of atropine and pressure dressing after operation, while the control group was only treated with pressure dressing. After treatment, postoperative complications such as salivary fistula in the two groups were observed. The results showed that the incidence of postoperative salivary fistula in the observation group was 4.76%, which was significantly lower than that in the control group (23.68%), the difference between the two groups was statistically significant (p<0.05); the grading of postoperative salivary fistula in the observation group was significantly lower than that in the control group (p<0.05); the average dressing time in the observation group was (10.48±1.30) d, which was significantly shorter than that in the control group (14.50±1.56) d, the difference was statistically significant (p<0.05). There was no significant difference between the observation group and the control group in postoperative periauricular numbness and Frey syndrome (p>0.05). The results showed that oral administration of atropine after parotid tumor resection could promote wound healing, reduce the occurrence of postoperative salivary fistula, shorten the time of compression bandage, and have good clinical application value.