长春地区女性亚临床甲状腺功能减退症与血脂异常的相关性分析

Analysis on the correlation between subclinical hypothyroidism and dyslipidemia in women in Changchun

目的探讨女性亚临床甲状腺功能减退症(简称亚临床甲减)与血脂异常的相关性,为女性亚临床甲减人群调节脂质紊乱提供参考依据。方法选取2014年9-12月在吉林大学第一医院就诊的长春地区女性为研究对象,对其进行甲状腺疾病的流行病学调查,包括一般资料问卷调查、相关体格检查、甲状腺功能和血脂代谢等实验室指标检查。结果长春地区女性亚临床甲减发生率为12.59%。女性亚临床甲减患者三酰甘油(TG)及低密度脂蛋白胆固醇(LDL-C)水平显著高于正常人群,升高风险分别是甲功正常人群的2.49倍和1.82倍,差异有统计学意义(P<0.05)。促甲状腺激素(TSH)>10mIU/L时,其TG升高风险是正常人群的4.96倍,差异有统计学意义(P<0.05)。结论女性亚临床甲减人群的血脂异常与TSH存在直接相关性,TSH>10mIU/L可明显增加TG水平升高的风险。

Objective To explore the correlation between subclinical hypothyroidism and dyslipidemia in women,provide a reference basis for regulating dyslipidemia in women with subclinical hypothyroidism.Methods From September to December in 2014,an epidemiological survey of thyroid diseases in women in Changchun was conducted,the survey contents included general information questionnaire,related physical examination,and laboratory tests,such as thyroid function and lipid metabolism.Results The incidence rate of subclinical hypothyroidism in women in Changchun was 12.59%.The levels of triacylglycerol ( TG) and low-density lipoprotein cholesterol ( LDL-C) in women with subclinical hypothyroidism were statistically significantly higher than those in normal population ( P<0.05) ,the risks were 1.49 and 0.82 times more than those of normal population.When thyroid stimulating hormone ( TSH) level was more than 10 mIU/L,the risk of hypertriglyceridemia in women with subclinical hypothyroidism was 3.96 times more than that of normal population ( P<0.05) .Conclusion Lipid metabolism disorder in women with subclinical hypothyroidism is directly related to TSH,and TSH>10 mIU/L may significantly increase the risk of hypertriglyceridemia.