我院33例莫西沙星不良反应分析

Analysis of 33 Cases of Moxifloxacin Induced Adverse Reactions in Our Hospital

目的:探讨莫西沙星致不良反应(ADR)的发生规律与特点,为临床安全用药提供依据与参考。方法:采用回顾性研究方法,在空军军医大学第一附属医院(西京医院) 2016年1月～2017年12月上报的ADR报告中,提取33例莫西沙星所致ADR报告,对患者年龄、性别、给药途径、ADR累及系统/器官及主要临床表现、临床转归等进行分析。结果:33例莫西沙星引起的ADR中,男18例,女15例。一般的ADR 24例次,严重的ADR 9例次。注射途径给药所致ADR 31例次,口服给药途径所致ADR 2例次。ADR累及器官/系统以皮肤及其附件损害(12例次,24%)、消化系统损害(11例次,22%)及心血管系统损害(6例次,12%)等最多见。结论:莫西沙星所致ADR在临床中较为常见,注射途径发生例数较多,且累及多个器官系统,临床应用中应加强监测,减少药害事件。

Objective :To investigate the regularity and characteristics of the occurrence of moxifloxacin induced adverse reactions (ADR)to provide reference for rational drug use in clinics.Methods:Using a retrospective study method,33 cases of ADRs of moxifloxacin in Xijing hospital from January 1st,2016 to December 31st,2017 were collected.The age,gender of patients,route of administration and clinical manifestation were analyzed.Results:Among 33cases of ADRs,there were 18male patients and 15female patients.There were 24 cases of general adverse reactions and 9 cases of severe adverse reactions.Totally 31cases were caused by injection and 2 ones by oral administration.Totally 33 ADRs were involved in several systems such as skin and its appendages,digestive system,cardiovascular system and so on.Conclusion:Moxifloxacin induced ADRs are common in clinical use.The highest incidence rate is through intravenous administration,and multiple organ systems are involved,therefore,monitoring should be strengthened to reduce drug damage in clinical use.