摘要
ABO blood group system was firstly recognized by Landsteiner in 1900[1].Since then,the antigens of the ABO system (A,B and H determinants,respectively)have been shown to encompass complex carbohydrate structures [2].A and B antigen were synthesized by the sequential action of glycosyltransferases,with A and B glycosyltransferases catalyzing the addition of N-acetylgalactosamine and D-galactose to precursor H antigen,respectively. Group O individuals lack such transferase enzymes and consequently continue to express the basic H structure only [3,4].It is determined that approximate 2million ABH glycan antigen sites are presented on each red blood cell [5].Additionally,the ABH antigens are widely expressed in other human ceils and tissues,including the sensory neurons,epithelium,the vascular endothelium and platelets [6].
基金
financially supported by the State Key Laboratory of Microbial Technology Projects Fund and the National Natural Science Foundation of China (31770997)
the Science and Technology Program of Guangdong Province (2016A020216021)
the Major International Joint Research Program of China (31420103901)
the Program of Introducing Talents of Discipline to Universities (B16021)