顺铂和奈达铂的临床应用

Clinical application of cisplatin and nedaplatin

多年的临床研究表明顺铂和奈达铂对大部分实体瘤如头颈部肿瘤、食管癌、肺癌、膀胱癌、卵巢上皮癌、睾丸癌和宫颈癌等有效,并且奈达铂在亚洲地区常常作为顺铂的替代药,但来自Ⅲ期临床试验的证据并不充足,临床医生在使用奈达铂替代顺铂治疗时应谨慎。

Cisplatin and nedaplatin have been proved to be effective for most of solid tumors including head and neck cancer, esophageal cancer, lung cancer, bladder cancer, ovary epithelial cancer, testicular cancer and cervical cancer. Nedaplatin is often used as an alternative to cisplatin in Asia. However, the evidence from phase Ⅲ clinical trials is insufficient. Clinicians should be cautious when using nedaplatin to replace cisplatin.