碘125放射性粒子插植治疗非小细胞肺癌的效果观察

Effect observation of iodine 125 radioactive particles implantation therapy on non-small cell lung cancer

目的探究分析碘125放射性粒子插植治疗非小细胞肺癌(NSCLC)的效果。方法 80例非小细胞肺癌患者,按照随机分配的方法分为研究组和对照组,每组40例。对照组患者采取常规长春瑞滨联合顺铂(NP方案)进行治疗,研究组患者在对照组基础上采用碘125放射性粒子插植进行治疗,比较两组患者的临床治疗效果、治疗后不良反应发生情况及治疗前后生活质量评分情况。结果研究组患者的总有效率95.0%明显高于对照组的72.5%,差异具有统计学意义(P<0.05)。治疗前,两组患者的社会功能、躯体功能、角色功能、认知功能各项评分比较,差异均无统计学意义(P>0.05);治疗后,研究组患者的社会功能、躯体功能、角色功能、认知功能各项评分均明显高于对照组,差异具有统计学意义(P<0.05)。研究组患者治疗后不良反应发生率12.5%明显低于对照组的32.5%,差异具有统计学意义(P<0.05)。结论采用碘125放射性粒子插植对非小细胞肺癌进行治疗,可有效地提高治疗效果,不良反应发生率得到明显降低,同时治疗后患者的生活质量明显高于单一采用常规的NP方案进行治疗,值得临床上广泛推荐使用。

Objective To investigate the effect of iodine 125 radioactive particles implantation therapy on non-small cell lung cancer.Methods A total of 80 patients with non-small cell lung cancer were divided into research group and control group according to the random distribution,with 40 cases in each group.Patients in the control group were treated with conventional vino'relbine combined with cisplatin (NP)regimen,patients in the research group were treated with radioactive particles implantation therapy on the basis of the control group.The clinical therapeutic effect,incidence of adverse reactions after treatment and quality of life before and after treatment between the two groups were compared.Results .The total effective rate of the research group was 95.0%,which was significantly higher than 72.5% of the control group,the difference was statistically significant (P<0.05).There were no significant differences in the scores of social function,physical function,role function and cognitive function between the two groups before treatment (P>0.05).After treatment,the scores of social function,physical function,role function and cognitive function in the research group were significantly higher than those in the control group,the differences were statistically significant (P<0.05).The incidence of adverse reactions in the research group was 12.5%,which was significantly lower than 32.5% in the control group,the difference was statistically significant (P<0.05).Conclusion The adoption of iodine 125 radioactive particles implantation therapy on non-small cell lung cancer,can effectively improve the treatment effect,the incidence of adverse reactions has been significantly reduced,at the same time,the quality of life of patients after treatment is significantly higher than the single use of conventional NP regimen for treatment,so it is worth widely recommended in clinical use.