血清铁调素水平与脑出血预后结局的关系研究

Study on correlation between serum hepcidin level and prognosis of intracerebral hemorrhage

目的探讨血清铁调素(Hep)与脑出血(ICH)预后结局的关系。方法选取40例首发脑出血患者为观察组, 40例健康体检者为对照组。检测观察组患者发病后1、3、5、7 d血清铁调素水平的变化情况,并与对照组比较;观察组患者发病3个月后根据改良Rankins量表(mRS)评分不同分为预后好组和预后差组,比较观察组不同预后患者血清铁调素水平。结果观察组患者发病后1、3、5、7 d血清铁调素水平分别为(74.05±11.36)、(111.54±11.73)、(91.56±10.54)、(79.05±11.21)ng/ml,均高于对照组的(48.68±28.68)ng/ml,差异具有统计学意义(P<0.05)。发病后3个月,观察组预后好患者25例,预后差患者15例。预后差组患者发病后1、3、5、7 d血清铁调素水平分别为(98.56±12.48)、(147.58±15.03)、(130.42±11.35)、(110.39±14.23)ng/ml均高于预后好组的(59.35±10.24)、(89.92±8.43)、(68.25±9.72)、(60.24±8.19)ng/ml,且预后差组患者血清铁调素平均水平(121.74±22.20)ng/ml显著高于预后好组患者的(69.44±15.37)ng/ml,差异具有统计学意义(P<0.05)。发病后3 d,两组患者血清铁调素水平均高于本组患者发病后1、5、7 d,差异具有统计学意义(P<0.05),两组患者血清铁调素水平均在脑出血发病后3 d达到高峰。结论血清铁调素水平与脑出血的发生、预后有密切关系。

Objective To discuss the correlation between serum hepcidin(Hep) level and prognosis of intracerebral hemorrhage(ICH). Methods 40 patients with first-episode intracerebral hemorrhage were selected as experimental group, and 40 healthy subjects were selected as control group. The changes of serum ferritin levels in the observation group were detected at 1, 3, 5 and 7 d after onset, and compared with those in the control group. The experimental group were divided into good prognosis group and poor prognosis group according to the modified Rankins scale(mRS) score after 3 months of onset. The serum hepcidin levels in the observation group were compared. Results The observation group had serum hepcidin level after 1, 3, 5 and 7 d of onset respectively as(74.05±11.36),(111.54±11.73),(91.56±10.54) and(79.05±11.21) ng/ml, which were all higher than(48.68±28.68) ng/ml in the control group, and their difference was statistically significant(P<0.05). After 3 months of onset, the observation group had 25 cases with good prognosis and 15 cases with poor prognosis. Poor prognosis group had higher serum hepcidin level after 1, 3, 5 and 7 d of onset respectively as(98.56±12.48),(147.58±15.03),(130.42±11.35) and(110.39±14.23) ng/ml than(59.35±10.24),(89.92±8.43),(68.25±9.72) and(60.24±8.19) ng/ml in good prognosis group, and good prognosis group had significantly higher serum hepcidin level as(121.74±22.20) ng/ml than(69.44±15.37) ng/ml in poor prognosis group. Their difference was statistically significant(P<0.05). After 3 d of onset, both groups had higher serum hepcidin level than those 1, 5 and 7 d after onset, and their difference was statistically significant(P<0.05). The serum hepcidin level in the two groups reached the peak at 3 d after the onset of intracerebral hemorrhage. Conclusion The serum hepcidin level is closely related to the occurrence and prognosis of intracerebral hemorrhage.