成釉细胞瘤相关信号通路研究进展

Research progress of signal pathway related to ameloblastoma

成釉细胞瘤是位于颌骨内较常见的牙源性上皮性肿瘤,主要临床表现为无痛、进行性、膨大性地生长,并伴有局部侵袭性。目前,其最主要的治疗方式是外科手术,但患者术后复发率高,需经过多次手术治疗,这会给患者带来严重的面部畸形和心理障碍。近年来研究表明,多个信号通路中的调控因子、靶基因及分子间的相互作用都参与了成釉细胞瘤细胞增殖与凋亡等重要病理过程,为其非手术治疗方法提供理论依据。文章对成釉细胞瘤相关信号通路的研究进展做一综述。

The ameloblastoma is a common type of odontogenic tumor within the jaw bone. The main clinical manifestation of the tumor is the non-painful expansive proliferation accompanied by local invasion. Currently,the major therapy method is surgery. However,the recurrence rate remains high after surgery. Thus,the repeated surgery is needed to treat the ameloblastoma completely,which results in great facial damage and brings about psychological dysfunction to patients. In recent years,researches have shown that multiple regulatory factors,target genes and the interaction between molecules are reported to participate in the proliferation and apoptosis of the tumor cells in ameloblastoma,which provide theoretical evidence for non-surgical treatment methods. This review will focus on the progress of signal pathway related to ameloblastoma.