斑马鱼——一种新的模式生物在地方病领域的应用展望

Application prospects of a new model organism,Zebrafish,in the field of endemic diseases

斑马鱼作为一种新型的模式生物,因为其独特的生长发育方面的优势和转基因操作的便利性已被广泛应用于生命科学研究的各个方面。我国是地方病病情严重的国家,目前存在的问题是地方性氟中毒和地方性砷中毒以及碘缺乏病发病机制不清,而克山病和大骨节病病因不明,这为地方病的防治工作带来了很大困难。目前,应用于地方病病因及其机制研究的动物模型存在一些缺点和不足,而斑马鱼作为一种新的模式生物其优势恰好可以弥补这些不足,因此通过本文,对新的模式生物斑马鱼在地方病研究领域的应用进行了展望。

As a new model organism,Zebrafish has been widely used in many aspects of life science research for its unique advantages in growth and development and the convenience of transgenic manipulation. Endemic disease is serious in China.Currently,on one hand,the pathogenesis of endemic fluorosis,endemic arsenism and iodine deficiency disorders is unclear,on the other hand,the cause of Keshan disease and KashinBeck disease is still unknown.This poses great difficulties in the prevention and control of endemic diseases.At present,there are some shortcomings and deficiencies in the animal models used to study the etiology and mechanism of endemic diseases.However,the advantages of Zebrafish as a new model organism just can make up for these deficiencies.Therefore,this paper reviews the application prospects of a new model organism,Zebrafish,in the field of endemic diseases.