用中药汤剂治疗脑外伤后认知障碍并发肺部感染患者的作用

Therapeutic effects of a traditional Chinese medicine decoction on cognitive impairment complicated with pulmonary infection after traumatic brain injury

目的 探讨用中药汤剂治疗脑外伤后认知障碍并发肺部感染患者的作用. 方法选取2016年2月至2017年3月我院收治的80例脑外伤后认知障碍患者为研究对象,同时确诊伴有肺部感染,随机分为对照组与研究组,各40例.对照组常规给予抗生素及多奈哌齐治疗,研究组在对照组的基础上给予中药汤剂治疗,比较两组治疗前后简易精神状态检查表(MMSE)评分、肺部临床症状积分及不良反应发生情况. 结果 治疗后研究组MMSE评分高于对照组〔(20.11 ± 6.37)分和(23.88 ± 5.90)分,t=2.746 ,P=0.007〕,肺部临床症状积分低于对照组〔(6.13 ± 2.24 )分和(4.39 ± 2.01)分,t=3.656 ,P=0.000〕;两组不良反应总发生率比较差异无统计学意义(P>0.05). 结论脑损伤后认知障碍合并肺部感染的中药汤剂作用明显,可提高认知能力,改善肺部临床症状,安全性高,值得临床推广.

Objective To investigate the effects of a traditional Chinese medicine (TCM ) decoction on cognitive dysfunction complicated with pulmonary infection after traumatic brain injury . Methods From February 2016 to March 2017 ,80 patients with cognitive dysfunction after traumatic brain injury ,who also had lung infection at admission to our hospital ,were enrolled and randomly divided into a control group and an observation group ,with 40 cases in each. Patients in the control group received conventional treatment with antibiotics and donepezil ,and patients in the observation group were administered a TCM decoction in addition to what was given to the control group.Mini-mental state examination(MMSE)scores and pulmonary symptom scores before and after treatment as well as adverse reactions were compared between the two groups. Results After treatment ,MMSE scores were higher in the observation group than in the control group (23.88 ± 5.90 vs.20.11 ± 6.37 ,t=2.746 ,P=0.007) ,and pulmonary symptom scores were lower in the observation group than in the control group (4.39 ± 2.01 vs.6.13 ± 2.24 ,t = 3.656 ,P = 0.007 ). The total incidence of adverse reactions showed no significant difference between the two groups (P>0.05). Conclusions The TCM decoction has clear benefits and high safety in treating cognitive impairment complicated with pulmonary infection after brain injury. It can improve cognitive ability and clinical symptoms of the lungs ,and should be recommended.