摘要
脓毒症是由机体对感染的反应失调而导致危及生命的器官功能障碍。免疫抑制是脓毒症患者后期继发感染,包括多重耐药菌的产生,最终导致患者死亡的重要因素。本文通过脓毒症免疫抑制、抗菌药物耐药机制以及脓毒症免疫抑制所致继发性感染3个方面对脓毒症患者免疫抑制与继发性多重耐药菌感染的关系进行综述,从而帮助临床医生对脓毒症免疫抑制患者进行更好的管理,提高这类患者的长期存活率,降低其再住院率。
Sepsis is a life-threatening organ dysfunction caused by dysregulated host response to infection. Immunosuppression is an important factor of secondary infection in the late state of sepsis,including multi-drugs resistant bacteria,which ultimately leads to the death of patients.The aim of this article was to help clinical staffs better manage patients with sepsis,improve long-term survival rate of the patients,and reduce their re-hospitalization rate by reviewing the relationship between sepsis-induced immunosuppression and multi-drugs resistant bacteria through three aspects:the mechanism of sepsis-induced immunosuppression,the mechanism of antibiotic resistance and the relationship between sepsis-induced immunosuppression and secondary infections.
作者
蔡耿鑫
叶靖坤
温妙云
Cai Gengxin;Ye Jingkun;Wen Miaoyun(Guangdong Provincial General Hospital,South China University of Technology,Guangzhou 510006,Guangdong,China;Second Clinical Medical College of Southern Medical University,Guangzhou 510515,Guangdong,China;Department of Emergency &Critical Care Medicine,Guangdong General Hospital,Guangdong Academy of Medical Sciences,Guangzhou 510080,Guangdong,China)
出处
《中华危重病急救医学》
CAS
CSCD
北大核心
2018年第11期1095-1098,共4页
Chinese Critical Care Medicine
基金
广东省自然科学基金(2016A030313763)
广东省广州市科技计划项目(201707010322).
关键词
脓毒症
免疫抑制
继发性感染
多重耐药
Sepsis
Immunosuppression
Secondary infections
Multi-drugs resistance
