安神定志灵加减治疗心肝火旺型注意力缺陷多动障碍患儿的临床疗效研究

Clinical Curative Study of Using Modified Anshen Dingzhi Ling in the Treatment of Heart-liver Fire-excess Type Attention Deficit Hyperactivity Disorder in Children

目的:观察安神定志灵加减治疗心肝火旺型注意力缺陷多动障碍患儿的临床疗效研究。方法:选取2014年6月至2016年6月在邯郸市中医院和深圳市中医院接受治疗注意力缺陷多动障碍(ADHD)患儿60例,随机分为试验组30例,对照组30例;试验组患儿使用安神定志灵进行治疗,对照组患儿使用专注达(盐酸哌甲酯控释片)进行治疗,疗程为8周;在治疗结束后到医院进行复查,使用设计好的观察表和患儿病例,对患儿的临床资料、用药情况、中医证候量表、注意缺陷多动障碍量表及血清炎性因子等进行详细记录、分析。结果:经过治疗后试验组患儿和对照组患儿在注意缺陷和多动的障碍量表积分、中医证候的总积分都有不同程度的下降,试验组患者比对照组下降的更多,两组对比差异显著(P <0. 05);经过治疗后试验组患儿中医证候疗效总的有效率是83. 33%,对照组为70. 00%,两组对比差异有统计学意义(P<0. 05);试验组患儿疾病疗效总的有效率是80. 00%,对照组为66. 67%,两组对比差异有统计学意义(P<0. 05);治疗后两组患儿血清炎性因子IL-1β、IL-6及TNF-α较治疗前均明显降低,差异有统计学意义(P<0. 05),且试验组效果更佳。结论:安神定志灵加减治疗心肝火旺型注意力缺陷多动障碍患儿能取得较好的治疗效果。

Objective: Studying on the effect of using ADL Decoction in the treatment of heart-liver fire-excess type attention deficit hyperactivity disorder in children. Methods: From June 2014 to June 2016 to accept the treatment of attention deficit hyperactivity disorder in Handan hospital of traditional Chinese medicine and Shenzhen hospital of traditional Chinese medicine of60 cases,were randomly divided into experimental group 30 cases,30 cases in controlled group. The experimental group used the ADL treatment,patients in the controlled group using attention as( Methylphenidate Hydrochloride Controlled Release Tablets)were treated for 8 weeks. At the end of treatment to the hospital for examination,using the observation table and in children were designed,with the clinical data,medication,TCM syndrome scale,attention defect analysis hyperactivity disorder scale and serum inflammatory factors,such as detailed records. Results: After treatment the experimental group and the controlled group in the behavior score scale,attention deficit and hyperactivity disorder total score scale scores and TCM syndromes had different degrees of decline,the experimental group decreased more than the controlled group,significant differences between the two groups( P <0. 05). After a group of children the efficacy of TCM syndrome total effective rate after treatment was 83. 33%,70% in the controlled group,there were statistically significant differences between the two groups( P < 0. 05). Treatment of children with disease in experimental group the total effective rate was 80%,the controlled group was 66. 67%,difference between the two groups was statistically significant( P < 0. 05). After treatment,serum inflammatory factors IL-1 beta,IL-6 and TNF-alpha in the two groups were significantly lower than before treatment,the difference was statistically significant( P < 0. 05),and the experimental group had better effect. Conclusion: Using ADL in the treatment of heart-liver fire-excess type attention deficit hyperactivity disorder in children can achieve better therapeutic effect.