干眼动物模型与干眼药物研发

Dry eye animal models and dry eye drug development

干眼是目前常见的慢性眼表疾病,主要表现为眼表的慢性炎症并严重威胁视力。尽管干眼发病普遍,但特效的治疗药物却很少。这与干眼的多样性和相应动物干眼模型的匮乏有关。在药物开发过程中,临床前期的动物模型是评估在研药物安全性和治疗效果的重要环节。目前干眼研究中常见的造模方法有手术摘除泪腺、全身或局部药物诱导、人为介导自身免疫反应及基因工程介导的干眼,本文就近年来用于药物研发的干眼动物模型及其特点进行综述,为开发新的治疗药物提供参考.

Dry eye is the most common eye illness which manifests as a chronic inflammation on ocular surface and imposes significant threat to vision.Though dry eye is high prevalent,specific medication to treat this refractory disorder is very limited.The paucity of new drugs available can be attributed to wide range of severity distribution as well as lack of appropriate animal model.Animal disease model plays a significant role in preclinical drug screening and testing prior to clinical trial.Various techniques have been explored to create dry eye models for drug testing,including surgical removal of lacrimal gland,systemic or local drug induction,autoimmune eliciting,and genetic manipulation.This article reviewed the important dry eye models and their roles in development of dry eye drugs to provide insight and inspiration for clinicians and researchers.