联合治疗对急性缺血性脑卒中患者认知功能损害的影响研究

Study on the Effects of Combined Treatment for Acute Ischemic Stroke Patients with Cognitive Impairment

目的观察中西医结合治疗对急性缺血性脑卒中患者认知功能、β-Ap、 CysC的影响。方法选取符合诊断标准的80例患者,随机分为治疗组和对照组,各40例。治疗组给予口服银杏叶提取物片+针刺治疗+认知功能训练,对照组给予口服多奈哌齐+认知功能训练,疗程为12周。治疗前后分别进行蒙特利尔认知评估量表(MoCA)、简易精神状态检查量表(MMSE)测评,并检测血清β淀粉样蛋白(β-Ap)、半胱氨酸蛋白酶抑制剂C (CysC)水平。结果两组治疗后的MoCA评分、MMSE评分均较治疗前显著改善(P <0.05),且治疗组的MoCA评分、 MMSE评分均显著优于对照组(P <0.05);两组治疗后的β-Ap、 CysC均较治疗前显著下降(P <0.05),且治疗组的β-Ap、 CysC均显著优于对照组(P <0.05)。结论联合治疗能改善急性缺血性脑卒中患者的认知功能,提高MoCA、 MMSE评分,降低β-Ap、 CysC水平,改善患者的预后。

Objective To observe the effects of integrated traditional Chinese medicine and western medicine on the cognitive fimction,β-Ap and Cys C in patients with acute ischemic stroke.Methods 80patients who met the diagnostic criteria were randomly divided into two groups equally.The treatment group was treated with ginkgo biloba extract tablets +acupuncture therapy +cognitive function training,while the control group was treated with donepezil orally +cognitive function training.Both groups were treated for 12 weeks.Before and after treatment,patients were evaluated by Montreal Cognitive Assessment Scale (MoCA)and Mini-Mental State Examination Scale (MMSE),and the levels ofserum β-Ap and Cys C were detected.Results After treatment,both groups had significantly improved MoCA and MMSE scores compared with those before treatment (P <0.05),and the MoCA and MMSE scores of the treatment group were significantly better than those of the control group (P <0.05).After treatment,both groups had significantly decreased levels of β-Ap and Cys C compared with those before treatment (P<0.05),and the levels of β-Ap and Cys C of the treatment group were significantly better than those of the control group (P<0.05).Conclusions Combined treatment can improve the cognitive function of patients with acute ischemlc stroke,improve the scores of MoCA and MMSE,reduce the levels offl-Ap and Cys C,and improve the prognosis of patients.