生长抑素联合泮托拉唑治疗重症急性胰腺炎的疗效及对炎性因子的影响

Curative Effect of Somatostatin Combined With Pantoprazole for the Treatment of Severe Acute Pancreatitis and the Impact

目的探讨生长抑素联合泮托拉唑治疗重症急性胰腺炎的疗效及对炎性因子的影响。方法选取我院2014年2月至2018年2月收治的86例重症急性胰腺炎患者,随机均分为两组。对照组采用泮托拉唑治疗,观察组采用生长抑素联合泮托拉唑治疗,比较两组患者的临床疗效以及治疗前后的炎性因子水平。结果观察组的总有效率为95.35%,显著高于对照组的76.74%(P <0.05)。治疗前,两组的TNF-α、 TGF-β、 IL-8水平无统计学差异(P>0.05);治疗后,观察组的TNF-α、 TGF-β、 IL-8水平均显著低于对照组(P <0.05)。结论生长抑素联合泮托拉唑可提高重症急性胰腺炎的疗效,降低炎性因子水平。

Objective To explore the curative effect of somatostatin combined with pantoprazole for the treatment of severe acute pancreatitis and the impact on the inflammatory factors.Methods 86cases of patients with severe acute pancreatitis admitted to our hospital from February 2014to February 2018were selected and randomly divided into two groups,with 43cases in each group.The control group was treated with pantoprazole,while the observation group was treated with somatostatin combined with pantoprazole.The clinical curative effects,as well as the levels of inflammatory factors before and after treatment were compared between the two groups.Results The total effective rate of the observation group was 95.35%,significantly higher than 76.74%of the control group (P <0.05).Before treatment,no statistical difference was found between the two groups in the levels of TNF-α,TGF-β and IL-8(P>0.05);After treatment,the levels of TNF-α, TGF-β and IL-8of the observation group were significantly lower than those of the control group (P <0.05).Conclusions Somatostatin combined with pantoprazole can improve the curative effect for severe acute pancreatitis,and reduce the levels of inflammatory factors.