帕罗西汀治疗缺血性脑卒中后合并抑郁焦虑障碍的临床观察

Clinical Observation of Paroxetine in the Treatment of Depression-Anxiety Disorder After Ischemic Stroke

目的探讨帕罗西汀对缺血性脑卒中后合并抑郁焦虑障碍患者的治疗效果。方法选择缺血性脑卒中后合并抑郁焦虑障碍患者82例,随机分为两组各41例。对照组采用常规缺血性脑卒中治疗,研究组在对照组基础上采用帕罗西汀治疗,比较两组的抑郁、焦虑以及神经功能缺损情况。结果治疗1个月、 2个月、 3个月后,研究组的HAMD、 HAMA评分均显著低于对照组(P <0.05)。治疗2个月、 3个月后,研究组的NIHSS评分显著低于对照组(P <0.05)。结论帕罗西汀治疗缺血性脑卒中后合并抑郁焦虑障碍患者,可有效调节负性情绪,改善预后,减轻神经功能缺损程度。

Objective To investigate the effect of paroxetine in the treatment of patients with depression-anxiety disorder after ischemic stroke.Methods 82cases of patients with depression-anxiety disorder after ischemic stroke were selected and randomly divided into the control group and the study group equally.Beth groups were treated with regular therapy of ischemic stroke;in addition,the study group was treated with paroxetine.The depression,anxiety and neurological deficit were compared between the two groups.Results At 1 month,2months and 3months of treatment,the HAMD score and HAMA score of the study group were significantly lower than those of the control group (P<0.05).At 2months and 3months of treatment,the NIHSS scores of the study group were significantly lower than those of the control group (P<0.05).Conclusions Paroxetine in the treatment of patients with depression-anxiety disorder after ischemic stroke can effectively regulate the negative emotions,improve the prognosis,and reduce the degree of neurological deficit.