ASTEMI患者术前服用负荷剂量替格瑞洛对PCI术中冠状动脉血流及预后的影响

Effect of Preoperative Oral Administration of Loading Dose of Ticagrelor on the Coronary Flow During PCI Operation and Prognosis in Patients with ASTEMI

目的观察ASTEMI患者PCI术前应用负荷剂量替格瑞洛对患者术中冠脉血流及预后的影响。方法 120例行PCI治疗的ASTEMI患者按入院顺序均分为替格瑞洛组和氯吡格雷组,术前分别给予替格瑞洛180 mg和氯吡格雷600 mg治疗,比较两组的干预效果。结果替格瑞洛组的术后心肌酶达到峰值时间、 CTFC及无复流/慢血流发生率均显著低于氯吡格雷组, TIMI 3级、 TMPG 3级比例均显著高于氯吡格雷组(P <0.05)。随访6个月,替格瑞洛组的MACE发生率低于氯吡格雷组(P <0.05)。结论 ASTEMI患者PCI术前服用负荷剂量替格瑞洛能够有效改善术中冠脉血流,降低术后MACE发生率。

Objective To observe the effect of preoperative oral administration of loading dose of ticagrelor on the coronary flow during PCI operation and prognosis in patients with ASTEMI.Methods 120cases of ASTEMI patients with PCI operation were divided into two groups according to the admission order.Before operation,the ticagrelor group received 180mg ticagrelor,while the clopidogrel group received 600mg clopidogrel.The intervention effects of the two groups were compared.Results The postoperative myocardial enzyme peak time,CTFC and incidence of no reflow /slow blood flow of the ticagrelor group were significantly lower than those of the clopidogrel group (P<0.05).The proportions of 3degree TIMI and 3degree TMPG of the ticagrelor group were significantly higher than those of the clopidogrel group (P<0.05).At 6months after operation,the incidence of MACE of the ticagrelor group was significantly lower than that of the clopidogrel group (P <0.05).Conclusions The oral administration of loading dose of ticagrelor before PCI operation in ASTEMI patients can effectively improve the intraoperative coronary blood flow,and reduce the incidence of postoperative MACE.