新生神经与结直肠癌研究进展

Advance in neurogenesis and colorectal cancer

近年来研究表明,作为肿瘤微环境的重要组成部分,神经在肿瘤的发生和发展过程中发挥着重要的作用。其中,神经周浸润(perineural invasion,PNI)已成为许多恶性肿瘤的关键病理学特征之一。结直肠癌具有富含自主神经纤维的内在特征,因此神经纤维的存在与结直肠癌患者的不良预后密切相关。然而新生神经与结直肠癌相互作用的潜在机制尚未明确,有关PNI现象是癌细胞主动入侵还是新生神经主动伸入尚无定论。目前,PNI及新生神经发生等过程是结直肠癌研究的一个重要部分,新生神经如何在肿瘤微环境中发挥作用也是一个研究重点。本文围绕结直肠癌中新生神经与肿瘤微环境其他组分相互作用的最新研究进展进行综述,旨在明确PNI的发生机制,以期为制定结直肠癌防治策略提供新的思路。

Recent studies have shown that, as an important part of tumor microenvironment, nerves play an important role in the occurrence and development of tumor. Perineural invasion (PNI) has become one of the key pathological features of many malignant tumors. Colorectal cancer is characterized by an abundance of autonomic nerve fibers, so the nerve fibers are closely related to the poor prognosis of colorectal cancer patients. However, the underlying mechanism of the interaction between neurogenesis and colorectal cancer has not been clarified, and it is inconclusive whether PNI is due to the active invasion of cancer cells or the active extension of neurogenesis. The process of PNI and neurogenesis is an important part of colorectal cancer research, and the role of neurogenesis in tumor microenvironment is also a research focus. In this paper, the latest research progress on the interaction of neurogenesis with other components of tumor microenvironment in colorectal cancer is reviewed in order to clarify the mechanism of its occurrence and provide new ideas for the prevention and treatment of colorectal cancer.