维生素D在子宫内膜异位症中的作用研究进展

Research progress on roles of vitamin D in endometriosis

维生素D除了调节机体钙磷代谢维持骨骼强壮外,还具有免疫调节、抗炎等作用,与慢性炎症性疾病、免疫疾病、肿瘤等有关。近年研究发现,维生素D可通过调节免疫、炎症反应、细胞增殖及凋亡、血管生成、细胞黏附及侵袭等方面参与子宫内膜异位症的发病;补充维生素D可缓解子宫内膜异位症相关疼痛,改善内膜容受性,防治子宫内膜异位症。本文就近年来维生素D在子宫内膜异位症中的作用及机制研究进展作一综述。

In addition to regulating calcium and phosphorus metabolism to maintain strong bones,vitamin D also has immune regulating and anti-inflammatory effects. Moreover,it is related to chronic inflammatory diseases,autoimmune diseases and cancer.Many studies indicate the roles of vitamin D in the development and progression of endometriosis including the effects on modulation of immune responses,inflammation reactions,cell proliferation and apoptosis,angiogenesis,adhesion and invasion. Vitamin D supplementation can relieve pain and improve endometrial receptivity associated with endometriosis and play a preventive and therapeutic role.This paper summarizes the roles of vitamin D in endometriosis.