氧化应激在子宫内膜异位症发病机制中的研究进展

Research progress on oxidative stress in pathogenesis of endometriosis

近年来大量研究表明,子宫内膜异位症患者体内普遍存在氧化应激现象。线粒体呼吸链异常、雌激素代谢失衡、内环境铁过载和子宫内膜异位病灶可导致活性氧增多,抗氧化酶和非酶类物质减少导致患者体内抗氧化水平减弱,而环境因素则会加剧子宫内膜异位症患者的氧化抗氧化失衡。本文从氧化物过度产生和抗氧化能力下降两方面分析氧化应激及其在子宫内膜异位症发病中的作用,旨在为发现子宫内膜异位症新的治疗方案提供思路。

A large number of studies have shown that the oxidative imbalance is common in patients with endometriosis. Abnormal respiratory chain of mitochondrial, estrogen metabolism imbalance,iron overload,and ectopic foci may increase active oxygen,reduction of antioxidant enzyme and non-enzymatic substances may result in decreased antioxidant level,and the exposure to environmental hazards may further aggravate oxidative imbalance in patients with endometriosis. This article analyzes the oxidative imbalance and its role in the pathogenesis of endometriosis from the aspects of excessive oxide production and decreased antioxidant capacity.