乳腺癌非特异性免疫微环境的研究进展

Research progress on nonspecific immune microenvironment in breast cancer

乳腺癌肿瘤免疫微环境,即浸润到乳腺肿瘤内部的免疫细胞及所分泌的活性介质等与肿瘤细胞共同构成的局部内环境,对肿瘤的生长、增殖及转移有着重要调控作用。除了由获得性免疫反应T淋巴细胞介导特异性抗肿瘤免疫反应的肿瘤杀伤效应,由NK细胞、树突状细胞、髓源性抑制细胞、肿瘤相关巨噬细胞、IL、趋化因子、TNF-α和TGF-β等非特异性免疫细胞及分子所介导的非特异性免疫反应作为抗肿瘤免疫的第一道防线,在清除肿瘤细胞、抑制其增殖具有重要作用。本文就近年来乳腺癌肿瘤微环境中参与非特异性免疫效应的相关机制研究作简要综述。

The immune microenvironment plays an important role in the occurrence and development of breast cancer. The infiltrating immune cells and the produced inflammatory cytokines in the tumor microenvironment regulate the growth,proliferation and metastasis of breast cancer. In this article,the roles and related mechanisms of nonspecific immune microenvironment in breast cancer are summarized,focusing on the natural killer cells,dendritic cells,myeloid derived suppressor cells,tumor associated macrophages,interleukins,chemokines,tumor necrosis factor-α,transforming growth factor-β and so on.