基于SPECT/CT平台设计的激光导航系统在经皮胸腔穿刺活组织检查中的应用

Application of laser navigation system in percutaneous transthoracic needle biopsy based on a SPECT/CT platform

目的探讨基于SPECT/CT平台设计的激光导航系统(LNS)在提高影像引导的经皮胸腔穿刺活组织检查(PTNB)效率中的价值。方法回顾性分析2017年1月至2017年10月间25例[男17例、女8例,年龄(58.9±10.8)岁]行99Tcm-甲氧基异丁基异腈(MIBI)SPECT/CT显像的肺部肿块患者资料,以病灶内最高摄取区作为取样靶区,行SPECT/CT引导的PTNB。其中13例患者行徒手穿刺(对照组),另12例行LNS辅助的徒手穿刺(LNS组)。比较2种穿刺方法的操作时间、CT引导次数及患者平均有效辐射剂量。采用两样本t检验分析数据。结果与对照组相比,LNS组穿刺操作时间明显缩短[(7.6±2.2)与(24.2±9.8)min,t=5.693,P<0.001],CT引导次数减少(1.9±0.9与4.0±1.5;t=4.108,P<0.001),患者平均有效辐射剂量降低[(7.7±0.9)与(10.5±2.1)mSv;t=4.306,P<0.01]。结论LNS有助于提高基于SPECT/CT平台的影像引导PTNB效率。

Objective To evaluate the value of a novel laser navigation system (LNS) designed for a SPECT/CT platform in improving efficiency of molecular imaging-guided percutaneous transthoracic needle biopsy (PTNB). Methods From January 2017 to October 2017, a total of 25 patients (17 males, 8 females, age (58.9±10.8) years) with thoracic lesions suspicious for malignancy underwent 99Tcm-methoxyisobutylisonitrile (MIBI) SPECT/CT-guided PTNB, and the hyperactivity areas were chosen as the sampling areas. Thirteen patients underwent traditional free hand puncture (control group), and 12 patients had LNS-assisted puncture (LNS group). The operation time, CT-guided times, average effective radiation dose of the two methods were compared. Two-sample t test was used to analyze the data. Results Comparing to control group, LNS-assisted PTNB puncture significantly reduced operation time ((7.6±2.2) vs (24.2±9.8) min; t=5.693, P<0.001), CT-guided times (1.9±0.9 vs 4.0±1.5; t=4.108, P<0.001) and average effective radiation dose ((7.7±0.9) vs (10.5±2.1) mSv; t=4.306, P<0.01). Conclusion The novel LNS is helpful in improving efficiency of molecular imaging-guided PTNB based on a SPECT/CT platform.