Ⅱa类组蛋白去乙酰化酶及抑制剂在胰岛素抵抗与糖尿病中的潜在作用（英文）

The Class Ⅱa Deacetylase and Its Inhibitors: Possible Therapies for Insulin Resistance and Type 2 Diabetes

Ⅱ类组蛋白去乙酰化酶(HDACs)包括HDAC4、5、7和9,它们能够发生磷酸化作用和介导核质转位。HDACs在肝、脂肪组织中的糖脂代谢中发挥作用,可加重胰岛素抵抗程度和糖尿病进展。Ⅱ类HDACs抑制剂目前已成为研究热点,旨在抑制酶活性,改善代谢和胰岛素敏感性。

Class Ⅱ histone deacetylases (HDACs) include HDAC4, 5, 7 and 9, which are subject to phosphorylation, thereby regulating their nuclear and cytoplasmic translocation. They play a role in glycolipid metabolism in liver and adipose tissues, thus aggravating the degree of insulin resistance and the progression of diabetes. Inhibitors of class Ⅱ HDACs have become a hot research topic. They aim to inhibit enzymatic activities, improve metabolism and insulin sensitivity.