摘要
治疗药物监测在临床诊疗实践中发挥着越来越重要的作用。本文通过临床药师参与1例行异基因造血干细胞移植后低蛋白血症并肺部感染的患者应用伏立康唑抗真菌的治疗,监测伏立康唑血药浓度,分析确定肝损伤不良反应发生的原因为伏立康唑导致的药物性肝损伤。药师建议及时停药,医师采纳,患者不良反应逐渐好转,避免了伏立康唑对肝脏的进一步损伤,对保障患者安全用药具有一定意义。
Therapeutic drug monitoring plays an increasingly important role in clinical practice.In this article,a clinical pharmacist participated in the anti-fungal treatment with voriconazole for a patient with hypoproteinemia and lung infection after allogeneic hematopoietic stem cell transplantation.By monitoring the plasma concentration of voriconazole,the pharmacist identified the causes of adverse reactions to liver injury. The physician adopted the pharmacist's suggestion and end voriconazole use timely.The patient's adverse reaction was gradually eased,and further damage to the liver caused by voriconazole was avoided.
作者
冯婷婷
胡梦笛
李琴
范国荣
FENG Ting-ting;HU Meng-di;LI Qin;FAN Guo-rong(Department of CliniealPharmacy,Shanghai General Hospital Shanghai Jiao Tong University,Shanghai 200080;School of Medicine,Shanghai Jiao Tong University, Shanghai 200025;Shanghai Key Laboratoryfor Pharmaceutical Metabolite Research,Shanghai 200433)
出处
《中南药学》
CAS
2018年第12期1674-1676,共3页
Central South Pharmacy
基金
上海市卫计委重要薄弱学科建设--临床药学(No.2016ZB0302)
关键词
伏立康唑
治疗药物监测
肝损伤
不良反应
voriconazole
therapeutic drug monitoring
liver injury
adverse reaction
