卵巢癌靶向治疗的研究现状

Progress in Targeted Therapy for Ovarian Cancer

卵巢癌是女性生殖器官最常见的恶性肿瘤之一,其治疗方法主要以手术及术后联合化疗为主,虽然手术技能与化疗方案不断地改进,但卵巢癌的死亡率在妇科恶性肿瘤中仍居首位。靶向治疗是针对恶性肿瘤的一种新兴治疗手段,利用肿瘤细胞与正常组织间分子生物学的差异,有选择性地作用于特定因子、酶类以及信号通路,抑制癌细胞的增殖甚至直接杀死癌细胞。本文通过复习相关文献,对卵巢癌靶向治疗的研究现状进行总结,为卵巢癌靶向治疗的进一步研究及临床应用提供依据。

Ovarian cancer is one of the most common malignant tumors in female genital organs.The main treatments of ovarian cancer include surgery and postoperative chemotherapy.Although surgical skills and chemotherapeutic strategies de- velop,the mortality rate of ovarian cancer is still the highest in gynecologic cancers.Targeted therapy is a new way to treat malignant tumor,which takes advantages of the divergence in the molecular biology between tumor cells and normal cells. Targeted therapy seleetively manipulate specific factors,enzymes,or pathways,thereby killing and/or inhibiting the prolifer- ation of tumor cells.There are many studies about targeted therapy of ovarian cancer,our study reviewed the current status of targeted therapy for ovarian cancer by reading literature,and provides a basis for further research and clinical application of targeted therapy for ovarian cancer.