金百合剂治疗小儿急性病毒性咳嗽的临床疗效观察

Clinical efficacy observation of Jinbai Mixture in treating acute viral cough in children

目的观察金百合剂治疗小儿急性病毒性咳嗽的临床疗效。方法将符合观察标准的270例小儿急性病毒性咳嗽患儿随机分为金百组、清热止咳组、易坦静组,分别予以金百合剂、小儿清热止咳口服液、易坦静单药治疗,疗程5天。观察患儿症状分级量化指标并评价临床疗效,观察治疗前后中医证候积分的变化及临床试验过程中是否出现不良事件。结果治疗前各组性别、年龄及病程均无统计学差异。金百组、清热止咳组、易坦静组临床总有效率分别为87.78%、72.22%和52.87%,金百组临床控制率明显优于清热止咳组和易坦静组(P<0.01);各组中医证候积分均较治疗前降低(P<0.01),其中金百组中医证候总积分减分差值显著高于清热止咳组(P<0.05)和易坦静组(P<0.01),咳嗽、咯痰积分减分差值大于清热止咳组和易坦静组(P<0.01)。各组均无用药不良事件。结论金百合剂可显著改善急性上呼吸道感染引起的小儿咳嗽痰多等临床症状,临床控制率显著。

Objective To observe the clinical efficacy of Jinbai Mixture in treating acute viral cough in children. Methods 270 children patients with acute viral cough who met the observation standard were randomly divided into Jinbai Mixture group,Qingre Zhike group anjing( ambroxol hydrochloride and clenbuterol hydrochloride oral solution) group,who were treated with Jinbai Mixture,Qingre Zhike Oral Solution and Yitanjing respectively,with a course of 5 days. The quantitative indexes of symptom grading in children were observed and the clinical efficacy was evaluated,the changes on TCM syndrome score were observed before and after treatment,and the adverse medical events occurred in the treatment were recorded. Results Before treatment,there were no statistical differences in gender,age and course of disease among groups.The total clinical effective rates were 87.78% in the Jinbai Mixture group,72.22% in the Qingre Zhike group and 52.87% in the Yitanjing group,respectively. The clinical control rate of the Jinbai Mixture group was obviously better than that of the Qingre Zhike group and Yitanjing group( P<0.01). The scores of TCM syndromes in all groups were decreased after treatment( P< 0.01). The D-value of total score of TCM syndrome between treatment before and after in the Jinbai Mixture group was significantly higher than that in the Qingre Zhike group( P<0.05) andYitajing group( P<0.01),and the D-value of cough score and expectoration score in the Jinbai Mixture group were greater than those in the Qingre Zhike group andYitajing group( P<0.01).No adverse reactions were found in all groups. Conclusion Jinbai Mixture can significantly improve the clinical symptoms of cough and excessive phlegm in children with acute upper respiratory tract infection,and the clinical control rate is significant.