络脉构效异常与脓毒症病理机制相关性探析

Correlation between collateral structure abnormality and pathological mechanism of sepsis

基于络病理论探析脓毒症的病理机制。脓毒症主要表现为络脉的气络损伤和血络瘀滞,二者相互影响,产生初期的免疫炎性反应(络热)、微循环内皮功能障碍(络痰)和凝血功能障碍(络瘀)、肠道细菌/内毒素移位与晚期炎症介质等(络毒),最终导致脓毒症的形成。

This article analyzes the pathological mechanism of sepsis based on the theory of collateral diseases. The main manifestations of sepsis are gas collateral damage and blood collateral stagnation. The two affect each other,which in turn triggers the early immune inflammatory response( collateral heat),microcirculation endothelial dysfunction( collateral phlegm),coagulation disorders( collateral stagnation) and intestinal bacteria/endotoxin translocation and advanced inflammatory mediators( collateral toxin),and eventually leads to the formation of sepsis.