山东省2014—2015年74例发热伴血小板减少综合征流行病学及临床特征

Epidemiological and clinical analysis of 74 cases of severe fever with thrombocytopenia syndrome in Shandong Province,China from 2014 to 2015

目的总结分析发热伴血小板减少综合征(SFTS)流行特征及临床特点。方法搜集2014—2015年济南市传染病医院收治的山东省74例SFTS患者的临床资料,包括流行病学、临床症状、体征及相关实验室检查等,进行回顾性分析。结果该病多发生于居住在山地丘陵地带的中老年农村居民,部分患者有蜱虫叮咬史。临床表现以发热伴全身症状及消化系统症状为主,重症患者可出现肺炎、消化道出血、多器官损害等。经抗病毒、对症支持治疗,46例临床治愈出院,12例住院期间死亡。16例放弃治疗,自动出院,随访其间13例死亡。结论 SFTS病情进展迅速,病死率高,应加强防病意识,早诊断、早治疗是关键。

Objective To summarize and analyze the epidemiological features and clinical characteristics of severe fever with thrombocytopenia syndrome (SFTS).Methods The clinical data of 74 patients with SFTS in Shandong Province were collected and retrospectively analyzed.They accepted treatment in Jinan Infectious Disease Hospital from 2014 to 2015.The data included epidemiology,clinical symptoms,signs and related laboratory tests.Results The disease occurred mostly in the elderly farmers living in hilly areas.Some patients had tick bites history.The clinical manifestations included fever,systemic symptoms and digestive system symptoms,and some severe patients also had pneumonia,gastrointestinal bleeding and multiple organ damage,etc.After antiviral and symptomatic treatments,46 cases were cured; 12 died during hospitalization;and 16 gave up treatment and left hospital voluntarily,and among them 13 died during follow-up.Conclusion SFTS progresses rapidly and has a high fatality rate.It is necessary to strengthen the awareness of disease prevention,and early diagnosis and treatment are the most important measures.