肠道菌群与结直肠癌的相关性研究

Relationship between the gut microbiota and colorectal cancer

结直肠癌(colorectal cancer,CRC)是常见的恶性肿瘤之一。CRC的发生是由环境、饮食及生活方式与遗传因素协同作用而引起的。近年来,肠道菌群在CRC中的作用越来越受到重视。诸多研究表明,肠道菌群及其代谢产物在结肠黏膜从正常上皮到腺瘤及癌变过程中起重要作用。本文就肠道菌群与CRC的最新研究进展作一概述。

Colorectal cancer (CRC)is one of the most common malignant tumors.The occurrence of CRC is a multifactorial and multi-stage involved disorder.In recent years,the relationship between the gut microbiota and CRC has attracted much scientific interest.Many studies show that gut microbiota and its metabolites play an important role in colonic mucosa from normal epithelium to adenoma and carcinogenesis.In this review,we discussed the relationship between CRC and gut microbiota.