因子V Leiden突变与中国青年缺血性卒中无关

Factor Ⅴ Leiden mutation is not associated with ischemic stroke in Chinese young adults

目的探讨凝血因子V Leiden突变与中国青年缺血性卒中的相关性。方法前瞻性纳/22016年7月至2018年1月在汕头大学医学院第一附属医院神经内科住院的青年(18~45岁)缺血性卒中患者及对照组各80例,记录人口统计学资料及血管危险因素,采用Sanger测序方法进行因子V Leiden突变检测。结果病例组和对照组因子V基因1691位点均为野生型。多变量logistic回归分析提示,高血压[优势比(odds ratio,OR)4.308,95%可信区间(confidence interval,CI)3.321~5.067;P=0.001]、高脂血症(OR 2.734,95%CI 2.214~3.378;P=0.005)和吸烟(OR 5.293,95%CI3.003~6.180;P=0.010)是青年缺血性卒中的独立危险因素,而高密度脂蛋白胆固醇(OR 0.611,95%C10.457~0.709;P=0.027)是其独立保护因素。结论因子V Leiden突变与中国青年缺血性卒中无关,高血压、血脂代谢异常及吸烟仍是青年缺血性卒中的主要危险因素。

Objective To study the correlation between coagulation factor V Leiden mutation and ischemic stroke in Chinese young adults.Methods From July 2016 to January 2018,80 young patients with ischemic stroke (18-45years)admitted to the Department of Neurology,the First Aff'tliated Hospital of Shantou University Medical College and 80controls were enrolled prospectively.The demographic data, vascular risk factors were documented.Sanger sequencing was used to detect factor V Leiden mutation. Results The 1691 sites of factor V genes in the case group and control group were all wild types. Multivariate logistic regression analysis suggested that hypertension (odds ratio [OR]4.308,95% confidence interval [CI]3.321-5.067;P =0.001),hyperlipidemia (OR 2.734,95%CI 2.214-3.378;P = 0.005),and smoking (OR 5.293,95%CI 3.003-6.180;P =0.010)were the independent risk factors for ischemic stroke in young adults,and high-density lipoprotein cholesterol (OR O.611,95%CI 0.457-0.709; P =0.027)wag its independent protective factor.Conclusion Factor V Leiden mutation is not associated with ischemic stroke in Chinese young adults.Hypertension,dyslipidemia and smoking are still the main risk factors for ischemic stroke in young adults.