维生素D治疗大肠埃希菌所致肠道炎症相关抑郁症的作用

The role of vitamin D in the treatment of Escherichia coli associated enteritis-related depression

目的研究维生素D对肠道微生态紊乱造成的抑郁的治疗作用。方法通过灌胃给予大肠埃希菌建立肠道紊乱模型,并外源给予维生素D。检测小鼠肠黏膜炎性因子的分泌和小鼠的抑郁情况。结果灌胃给予大肠埃希菌明显促进了肠黏膜促炎性因子的分泌并促使小鼠出现抑郁症状。外源性给予维生素D则明显降低了肠黏膜促炎性因子的分泌,并且缓解了小鼠抑郁的症状。结论维生素D可通过调节肠道菌群降低炎症反应,并缓解抑郁症状。

Objective To study the therapeutic effect of vitamin D on depression caused by intestinal microecological disorders.Methods Intestinal disturbance model was established by intragastric administration of E.coli,and vitamin D was given exogenously.The secretion of inflammatory factors in mouse intestinal mucosa and the depression of mice were detected.Results Gastric administration of E.coli significantly promoted the secretion of pro-inflammatory cytokines in the intestinal mucosa and promoted depressive symptoms in mice.Exogenous administration of vltamin D significantly reduced the secretion of pro-inflammatory cytokines in the gut mucosa and relieved the symptoms of depression in mice.Conclusion Vitamin D can reduce inflammation by regulating intestinal flora and relieve depressive symptoms.