肠道菌群的研究进展及与胆管癌的关系分析

Intestinal flora and cholangiocarcinoma:Research progress

人体肠道内生存着种类繁多的微生物,它们在维持人体健康及疾病的发生发展中发挥着重要的作用,被称为人体的"第二基因库"及"隐藏的器官"。近年来,随着人类微生物组计划(HMP)及人类肠道宏基因组计划(MetaHIT)的实施,关于肠道微生态的研究逐渐走向高潮,其中肠道菌群在胆管癌的发生发展中的作用逐渐显露出来。胆管癌作为一种预后极差且发病率逐渐升高的消化系肿瘤,其与肠道菌群的关系,特别是细菌逆行性感染及肠道微生态失衡在胆管癌病情进展中的作用应引起大家的重视。本文就肠道菌群的分布情况及其在胆管癌发生发展中的影响、检测方法及研究展望作一综述。

There are variety of microorganisms in human intestinal tract.They play an important role in the maintenance of human health and the development of diseases,and are called "the second gene pool"and " the hidden organ"in human body.With the implementation of the Human Microbiome Project (HMP)and the Human Intestinal Metagenomic Project (MetaHIT),studies on intestinal mieroecology is gradually reaching its climax,and the role of intestinal flora in the occurrence and development of cholangioearcinoma is gradually revealed.Cholangiocarcinoma is a digestive system tumor with poor prognosis.Its relationship with intestinal flora,especially the roles of retrograde bacterial infection and imbalance of intestinal microecology in the progression of cholangiocareinoma,should be paid attention.In this paper,the distribution of intestinal flora,its impact on the occurrence and development of cholangioearcinoma,the detection methods and research prospects are reviewed.