干细胞移植治疗新生儿缺氧缺血性脑病研究现状的可视化分析

A visualization analysis of current research on stem cell transplantation in the treatment of neonatal hypoxic-ischemic encephalopathy

目的展现干细胞移植治疗在新生儿缺氧缺血性脑病(HIE)中的研究现状,总结近些年该领域的研究热点。方法以"stemcells(干细胞)"和"hypoxic-ischemic encephalopathy(缺氧缺血性脑病)"作为关键词,在PubMed、EMBASE及Web of Science数据库检索2018年6月1日前发表的英文文献。利用Excel2013进行关键词统计,利用Bicomb2.0及VOSviewer1.6.6软件进行热点词汇聚类分析和绘制知识图谱。结果共纳入文献106篇,提取高频关键词43个。"细胞移植"和"缺氧缺血"在共现图中处于核心位置。聚类分析显示,目前干细胞移植在治疗新生儿HIE的研究主要集中在以下4个方面:(1)脐血细胞移植(32.6%);(2)间充质干细胞、神经干细胞相关研究(29.5%);(3)围产期脑损伤(28.1%);(4)其他研究(9.8%)。结论目前在新生儿HIE的干细胞移植治疗相关研究中,"脐血细胞移植""间充质干细胞""神经干细胞""围产期脑损伤"作为不同研究层面和热点受学者关注。

Objective To reveal the current research status on stem cell transplantation in the treatment of neonates with hypoxic-ischemic encephalopathy(HIE),and to summarize the recent hotspots of the research in this field.Methods Using the key words of "stem cells" and "HIE",a computerized search was performed for the articles in English published before June 1,2018 in PubMed,EMBASE,and Web of Science.Microsoft Office Excel 2013 was used for the statistical analysis of key words.Bicomb 2.0 and VOSviewer 1.6.6 were used for the cluster analysis of hot words and plotting of knowledge maps,respectively.Results A total of 106 articles were included and 43 highfrequency key words were extracted.The words of "cell transplantation" and "hypoxia-ischemia" were in the core position of the co-word map.The cluster analysis showed that the studies of stem cell transplantation in the treatment of neonatal HIE mainly focused on umbilical cord blood cell transplantation(32.6%),mesenchymal stem cells and neural stem cells(29.5%),perinatal brain injury(28.1%),and other topics(9.8%).Conclusions In the current studies of stem cell transplantation in the treatment of neonatal HIE,umbilical cord blood cell transplantation,mesenchymal stem cells,neural stem cells,and perinatal brain injury are popular research topics at different levels.