环氧化酶-2水平和脂代谢指标在糖尿病心肌病患者体内的变化特点及意义

Changes of COX-2 and lipid metabolism in patients with diabetic cardiomyopathy

目的研究环氧化酶-2(COX-2)水平和脂代谢指标在糖尿病心肌病患者体内变化特点及意义。方法选取46例糖尿病心肌病患者设为观察组,选取同期单纯糖尿病患者40例设为对照组。记录并比较两组患者血脂指标、B型脑钠肽(BNP)、COX-2、血管紧张素转移酶2(ACE2)、基质金属蛋白酶组织抑制剂-2(TIMP-2)、基质金属蛋白酶-1 (MMP-1)水平及心功能指标。结果观察组患者病程长于对照组,总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、BNP、COX-2、ACE2、TIMP-2、肌酸激酶同工酶(CK-MB)水平高于对照组,高密度脂蛋白胆固醇(HDL-C)、MMP-1、左室射血分数(LVEF)、E峰/A峰比值水平低于对照组,差异有统计学意义(P <0.05)。结论糖尿病心肌病患者体内BNP、COX-2、ACE2、TIMP-2水平显著上升,心功能指标下降,且脂代谢指标改变较为明显,为临床诊断糖尿病心肌病提供参考。

Objective To investigate the changes and significance of cyclooxygenase-2(COX-2) level and lipid metabolism in patients with diabetic cardiomyopathy(DM). Methods Forty-six patients with diabetic cardiomyopathy were selected as observation group and 40 patients with diabetes were selected as control group.The serum lipid,type B brain natriuretic peptide (BNP),angiotensin transferase (ACE2),tissue inhibitor of matrix metalloproteinase(MMP-2),matrix metalloproteinase-1(MMP-1) and cardiac function were recorded and compared between the two groups. Results The course of the observation group was longer than that in the control group.The total cholesterol TCU,triglyceride TGN,low density lipoprotein cholesterol BNP,COX-2,ACE2,TIMP-2 and creatine kinase isoenzyme CK-MB of the observation group were higher than those in the control group.The high density lipoprotein cholesterol (HDL-C),left ventricular ejection fraction (LVEF) and ratio of peak E/A were significantly lower than those in the control group(P<0.05),the difference was statistically significant. Conclusion The levels of serum BNP,COX-2,ACE2,TIMP-2 are increased significantly in patients with diabetic cardiomyopathy,and the cardiac function is decreased,and lipid metabolism changed significantly.