单相抑郁症患者各脑叶CT值的改变与分析

Change and analysis of CT values in each lobe of patients with unipolar depression

目的探讨分析单相抑郁症患者各脑叶CT值的改变情况及与病程的关系。方法选取我院收治的不同病程单相抑郁症患者5 0例为观察组,同时选取同期行健康体检者5 0例为对照组。两组均行颅脑CT扫描,对各脑叶CT值进行比较。结果观察组患者左额叶CT值、左、右颞叶CT值均明显低于对照组(P<0.05);两组右额叶CT值比较差异无统计学意义(P>0.05);且观察组患者各脑叶CT值比较,右颞叶明显高于其他脑叶(P <0.05);线性回归分析显示单相抑郁症患者左额叶、左颞叶CT值与年龄呈负相关(P <0.05),左额叶CT值与病程呈负相关(P<0.05)。结论单相抑郁症患者左额叶、左颞叶可见明显萎缩现象,且左额叶萎缩程度多与病程有密切关联,提示该病可能为中枢神经系统退行性疾病。

Objective To investigate the relationship between the changes of CT values of cerebral lobes and the course of disease in patients with unipolar depression.Methods A total of 50 cases of unipolar depression with different course were selected as the observation group,and 50 cases of normal people who underwent physical examination at the same time were selected as the control group.Results The CT values of left frontal lobe,left temporal lobe and right temporal lobe in the observation group were significantly lower than those in the control group(P<0.05),and there was no significant difference between the two groups(P>0.05),and the CT values of the right temporal lobe in the monophasic depression group were significantly higher than those in other lobes(P<0.05).The linear regression analysis showed that the CT value of left frontal lobe and left temporal lobe were negatively correlated with age (P<0.05),also the CT value of right frontal lobe was negatively correlated with course of disease (P<0.05).ConclusionThe atrophy of left frontal lobe and temporal lobe can be seen in patients with unipolar depression,and the degree of atrophy of left frontal lobe is closely related to the course of disease.