2型糖尿病与脑白质疏松认知损害的相关性研究进展

Progress in the relationship between type 2 diabetes mellitus and cognitive impairment in leukoaraiosis

2型糖尿病(T2DM)是一种常见的代谢紊乱疾病,其主要特征为慢性高血糖以及高血糖致使的多器官损害并发症。脑白质疏松(LA)或脑白质病变(WML),是一组由多种病因导致的脑内白质纤维变性而引发的一组临床综合征,主要表现为不同程度的认知损害甚至痴呆。近年来,T2DM与LA之间的相关性是神经科学领域研究的一个热点,T2DM可能是LA的重要危险因素,并可能加重其认知损害的发生。本文将对T2DM与LA的关系,以及其影像学表现与认知损害相关性问题研究进展进行综述,以更好地加深临床对LA的认识。

Type 2 diabetes mellitus(T2DM)is a common metabolic disorder..The main characteristics of T2DM are chronic hyperglycemia and multiple organ damage caused by hyperglycemia.Leukoaraiosis(LA)or white matter lesions(WML)is a group of clinical syndrome caused by various causes of degeneration of white matter fibers in the brain.The main manifestations are cognitive impairment and even dementia.In recent years,the correlation between T2DM and LA is a hot topic in neuroscience,T2DM may be an important risk factor for LA and may aggravate the occur- rence of cognitive impairment.This article will review the relationship between T2DM and LA ,as well as the relationship between imaging findings and cognitive impairment,in order to deepen the clinical understanding of LA.