中成药联合心理干预治疗动脉粥样硬化临床前期病变临床疗效观察

Clinical Observation on the Therapeutic Effect of Chinese Medicine Combined with Psychological Intervention on PCA

目的:探究中成药联合心理干预治疗动脉粥样硬化临床前期病变(PCA)的临床疗效及血清中apoA1、apoB的水平变化及意义。方法:通过观察临床中收集的PCA患者200例,将其分为西医治疗对照组100例(A组),中成药联合心理干预结合治疗组100例(B组);两组患者均进行常规西医治疗,中成药联合心理干预组在常规西医治疗基础上给予中成药通心脉颗粒及心理干预治疗,并检测患者治疗前后血清中载脂蛋白A1(apoA1)、载脂蛋白B(apoB)水平变化并比较检测值结果的差异,并与治疗前后疗效作对比,并对两组患者进行心理评估,探讨治疗的临床价值。结果:(1)两组患者治疗前后载脂蛋白A1(apoA1)明显升高(P<0.05),组间比较差异明显(P<0.05);两组患者治疗前后载脂蛋白B(apoB)明显降低(P<0.05),组间比较差异明显(P<0.05)。(2)两组患者治疗前后相比,心理抑郁评分明显降低;B组心理评分明显低于A组,且差异明显(P<0.05)。结论:(1)中成药联合心理干预治疗PCA患者的疗效高于单纯西医治疗,安全性高,疗效明显,并且明显提高了临床疗效。(2)载脂蛋白A1(apoA1)、载脂蛋白B(apoB)可以用来预测PCA患者疾病的严重程度及预后,并且可以根据检测结果对治疗效果进行评价。(3)临床治疗过程中,及时对患者进行心理等方面评价可以提高临床疗效改善患者预后,对患者的病程及预后有着更全面的了解与认识。(4)可以将通心脉颗粒运用到临床治疗PCA中去,可以改善患者的症状及远期预后,为临床医生提供了新的治疗方法。

Objective:To explore the clinical efficacy and the level of apoA1 and apoB in the treatment of PCA in combination with psychological intervention. Methods:200 cases of patients with clinical atherosclerosis preclinical lesions(PCA)were divided into two groups:Western medicine treatment group (group A,n =100)and traditional Chinese medicine combined with psychological intervention group(group B,n =100). The two groups of patients were treated with conventional Western medicine. The traditional Chinese medicine combined with psychological intervention group was treated with traditional Chinese medicine Tongxinmai Granule and psychological intervention. The levels of apolipoprotein A1(apoA1), apolipoprotein B(apoB)levels were compared and the difference between the detection results was compared with the curative effect before and after treatment,and the psychological evaluation of the two groups was carried out to explore the clinical value of treatment. Results:(1)Apolipoprotein A1(apoA1) was significantly increased in the two groups before and after treatment(P <0.05). There was significant difference between the two groups(P <0.05).(2)Compared with group A,the psychological score of group B was significantly lower than that of group A(P <0.05). Conclusion:(1)The efficacy of Chinese medicine combined with psychological intervention in the treatment of atherosclerosis patients with preoperative disease(PCA)is higher than that of western medicine alone. The safety is high and the curative effect is obvious,and the clinical curative effect is obviously improved. ApoB1 and apoB can be used to predict the severity and prognosis of atherosclerotic patients with early clinical disease(PCA)and to evaluate the therapeutic effect based on the test results.(3)The clinical treatment process,timely psychological evaluation of patients can improve the clinical efficacy of patients with prognosis,the patients' course and prognosis has a more comprehensive understanding and understanding.(4)Tongxinmai Granule can be Tongxinmai Granule applied to the clinical treatment of PCA,can improve the patients' symptoms and longterm prognosis,for clinicians to provide a new treatment.