刺玫籽醇提取物对力竭运动大鼠糖代谢的影响

Effects of ethanol extract of Rosa prickly seed on glucose metabolism of exhaustive exercise rats

研究刺玫籽醇提取物对力竭运动大鼠糖代谢的影响。将40只大鼠分为对照组、低剂量组(50 mg/kg)、中剂量组(100 mg/kg)、高剂量组(150 mg/kg)。大鼠每天分别灌胃1次刺玫籽醇提取物,以及每天1次游泳运动,为期4周。结果表明:低、中、高剂量组大鼠实验后血糖相比对照组显著上升(p <0. 05),低、中剂量组大鼠实验后血乳酸含量相比对照组显著降低(p <0. 05),高剂量组大鼠血乳酸含量相比对照组极显著降低(p <0. 01);低、中、高剂量组大鼠实验后肌糖原、肝糖原含量相比对照组显著上升(p <0. 05);实验后各组大鼠血糖、肌糖原、肝糖原含量与实验前平行对比有不同程度降低,而血乳酸含量有不同程度升高。研究说明刺玫籽醇提取物对力竭运动大鼠的糖代谢能力有良好的效果。

The effect of ethanol extract of Rosa prickly seed on glucose metabolism of exhaustive exercise rats were studied. Forty rats were divided into control group,low dose group( 50 mg/kg),medium dose group( 100 mg/kg) and high dose group( 150 mg/kg). Rats were administrated with ethanol extract of Rosa prickly seed once a day and swam once a day for four weeks. The results showed that the blood sugar of rats in low,medium and high dose groups significantly increased compared with control group after experiment( p < 0. 05). The blood lactic acid contents of rats in low and midium dose groups significantly decreased compared with control group after experiment( p < 0. 05),especially the blood lactic acid content of rats in high dose group very significantly decreased compared with control group( p < 0. 01). The liver glycogen and muscle glycogen contents of rats in low,medium and high dose groups significantly increased( p < 0. 05). The blood sugar,liver glycogen and muscle glycogen contents of rats in each group after experiment reduced to different extent compared with that before experiment,while the blood lactic acid contents of rats in each group after experiment increased to different extent compared with that before experiment. The research suggested that the ethanol extract of Rosa prickly seed had a good effect on the glucose metabolism of exhaustive exercise rats.