中药干预肺肾阴虚型癌因性疲乏

Chinese Materia Medica Intervening in Yin Deficiency of Lung and Kidney Type Cancer-Related Fatigue

目的:观察滋肾养肺汤治疗肺肾阴虚型癌因性疲乏的临床疗效及安全性。方法:60例肺肾阴虚型癌因性疲乏患者随机平均分为观察组和对照组。对照组给予常规治疗,观察组在对照组治疗基础上给予滋肾养肺汤,两组均治疗14 d。比较两组治疗前后Piper疲乏量表评分、中医证候积分、体质量。结果:观察组有效率为86. 66%,对照组有效率为25. 00%,两组比较,差异有统计学意义(P <0. 01)。观察组治疗前后疲乏量表总评分分别为(7. 34±0. 44)分、(6. 24±0. 53)分,对照组分别为(7. 28±0. 33)分、(7. 20±0. 47);观察组行为疲乏评分分别为(6. 54±0. 50)分、(5. 80±0. 56)分,对照组分别为(6. 62±0. 39)分、(6. 51±0. 25)分;观察组情感疲乏评分分别为(8. 02±0. 58)分、(6. 76±0. 62)分,对照组分别为(7. 99±0. 61)分、(7. 76±0. 23)分;观察组感知疲乏评分分别为(7. 89±0. 53)分、(6. 55±0. 60)分,对照组分别为(7. 87±0. 49)分、(7. 70±0. 45)分;观察组认知疲乏评分分别为(7. 68±0. 60)分、(6. 57±0. 68)分,对照组分别为(7. 71±0. 54)分、(7. 49±0. 54)分;两组患者治疗前后以上各项评分比较,差异均有统计学意义(P <0. 05);观察组治疗后评分均低于对照组治疗后,差异均有统计学意义(P <0. 05)。观察组治疗前后体质量分别为(58. 13±4. 32) kg、(58. 93±4. 37) kg,差异有统计学意义(P <0. 05)。结论:滋肾养肺汤可安全、有效改善肺肾阴虚型癌因性疲乏患者的疲乏症状,可降低Piper疲乏量表评分,提高肿瘤患者生存质量。

Objective: To observe the clinical efficacy and safety of Zishen Yangfei Decoction in the treatment of yin deficiency of lung and kidney type cancer-related fatigue. Methods: 60 patients with yin deficiency of lung and kidney type cancer-related fatigue were randomly divided into observation group and control group. The control group received routine treatment and the observation group was given Zishen Yangfei Decoction on the basis of the control group. Both groups were treated for 14 days. Piper fatigue scale score,TCM syndrome score and the body mass were compared before and after treatment in both groups. Results: The effective rate of the observation group was 86. 66%,and the effective rate of the control group was 25. 00%. The difference between the two groups was statistically significant ( P < 0. 01) . The total scores of the fatigue scale before and after treatment in the observation group were ( 7. 34 ± 0. 44) points and ( 6. 24 ± 0. 53) points respectively,and the control group were ( 7. 28 ± 0. 33) points and ( 7. 20 ± 0. 47) . The behavioral fatigue scores of the observation group were ( 6. 54 ± 0. 50) and ( 5. 80 ± 0. 56) respectively, and the control group were ( 6. 62 ± 0. 39) and ( 6. 51 ± 0. 25) respectively. The emotional fatigue scores of the observation group were ( 8. 02 ± 0. 58) points and ( 6. 76 ± 0. 62) points respectively,and the control group were ( 7. 99 ± 0. 61) points and ( 7. 76 ± 0. 23) points respectively. The observed fatigue scores of the observation group were ( 7. 89 ± 0. 53) points and ( 6. 55 ± 0. 60) points respectively,and the control group were ( 7. 87 ± 0. 49) points and ( 7. 70 ± 0. 45) points respectively. The cognitive fatigue scores of the observation group were ( 7. 68 ± 0. 60) and ( 6. 57 ± 0. 68) respectively,and the control group were ( 7. 71 ± 0. 54) and ( 7. 49 ± 0. 54) respectively. There were significant differences in the scores of the two groups before and after treatment ( P < 0. 05) . The scores of the observation group after treatment were lower than those of the control group,and the differences were statistically significant ( P < 0. 05) . The body masses of the observation group were ( 58. 13 ± 4. 32) kg and ( 58. 93 ± 4. 37) kg,respectively,and the difference was statistically significant ( P < 0. 05) . Conclusion: Zishen Yangfei Decoction can safely and effectively improve the fatigue symptoms of patients with yin deficiency of lung and kidney type cancer-related fatigue,reduce the Piper fatigue scale score,and improve the quality of life of cancer patients.