退白颗粒联合窄谱中波紫外线治疗寻常型白癜风

Tuibai Granule Combined with Narrow-band UVB in Treatment of Vitiligo Vulgaris

目的:观察中药退白颗粒联合窄谱中波紫外线治疗寻常型白癜风的临床疗效与安全性。方法:60例寻常型白癜风患者给予中药退白颗粒内服联合窄谱中波紫外线皮损局部照射治疗,疗程3个月。分别于治疗前和治疗后第1个月、第2个月、第3个月记录皮损色素积分,并观察皮损复色时间及窄谱中波紫外线维持治疗剂量,同时观察患者临床疗效。结果:治疗第1个月、第2个月、第3个月,所有患者皮损色素积分较治疗前均明显增加(P <0. 05,P <0. 01);且进展期患者增加幅度优于稳定期患者,皮损面积<5%患者优于皮损面积≥5%患者,病程<1年患者优于病程≥1年患者,差异均有统计学意义(P <0. 01)。治疗后皮损复色时间比较,进展期患者短于稳定期患者,皮损面积<5%患者短于皮损面积≥5%患者,病程<1年患者短于病程≥1年患者。窄谱中波紫外线维持治疗剂量比较,进展期患者少于稳定期患者,皮损面积<5%患者少于皮损面积≥5%患者,病程<1年患者少于病程≥1年患者,差异均有统计学意义(P <0. 05,P <0. 01);进展期患者有效率88. 24%,稳定期患者有效率61. 54%;皮损面积<5%患者有效率87. 10%,皮损面积≥5%患者有效率65. 52%;病程<1年患者有效率87. 50%,病程≥1年患者有效率64. 29%;两两配对比较,差异均有统计学意义(P <0. 05)。结论:退白颗粒联合窄谱中波紫外线对寻常型白癜风有良好的治疗作用,并且治疗进展期、皮损面积<5%、病程<1年患者效果更好。

Objective: To observe the clinical efficacy and safety of Chinese medicine Tuibai Granule combined with Narrow-band UVB in the treatment of vitiligo vulgaris. Methods: 60 patients with vitiligo vulgaris were given Chinese medicine Tuabai granules orally combined with narrow-band UVB local lesion irradiation treatment for 3 months. Skin lesion pigment scores were recorded before treatment and at 1 month,2 months,and 3 months after treatment. The time of skin lesions color recovery and the narrowspectrum UVB maintains therapeutic doses were observed,and the clinical efficacy was observed,too. Results: In the first month, the second month and the third month of treatment,the pigmentation scores of all patients were significantly increased compared with those before treatment ( P < 0. 05,P < 0. 01) , and the increase in patients in advanced stage was better than that in stable patients. Patients with lesion area < 5% are better than patients with lesion area ≥5%,and patients with disease duration < 1 year are better than patients with disease duration ≥1 year. The differences were statistically significant ( P < 0. 01) . After treatment, the time of skin lesions color recovery was compared. Patients in advanced stage were shorter than patients in stable stage. Lesion area < 5% of the patients was shorter than patients with lesion area ≥5%,and disease duration < 1 year of the patients was shorter than patients with disease duration ≥1 year. Compared the maintenance dose of narrow-band UVB,the patients in the advanced stage were less than the stable stage,and the lesion area < 5% of the patients was less than the lesion area ≥5%,and the disease duration < 1 year of the patients was less than the disease duration ≥1 year. The differences were statistically significant ( P < 0. 05,P < 0. 01) . The effective rate of patients in advanced stage was 88. 24%,and the effective rate of patients in stable stage was 61. 54%. The effective rate of lesions < 5% was 87. 10%,and the effective rate of lesions ≥5% was 65. 52%. The effective rate of patients < 1 year was 87. 50%. The effective rate of patients with disease course ≥1 year was 64. 29%. The differences between the two groups were statistically significant ( P < 0. 05) . Conclusion: Tuibai Granule combined with narrow-band UVB have a good therapeutic effect on vitiligo vulgaris,and it is more effective in patients in stable stage,lesion area < 5%,and disease duration < 1 year.