早期生大黄联合肠内营养治疗重症急性胰腺炎

Dahuang (Radix et Rhizoma Rhei) combined with enteral nutrition for severe acute pancreatitis in early stage

目的观察早期生大黄联合肠内营养治疗重症急性胰腺炎(SAP)的临床效果。方法选择2014年1月至2017年12收治的45例SAP患者。观察组25例,通过肠内营养管灌注生大黄和肠内营养液;对照组20例,通过肠内营养管灌注生大黄治疗。分别对两组患者的腹痛和腹胀缓解时间、胃肠功能恢复时间、血淀粉酶等生化指标进行比较。结果治疗1周后,观察组的血淀粉酶、血糖、CRP数值较对照组明显下降,血钙明显升高,差异具有统计学意义(P<0. 05);同时腹痛和腹胀缓解时间[(3. 25±0. 42) d]、[(3. 35±0. 53) d]、胃肠功能恢复时间[(3. 10±0. 45) d]均短于对照组[(4. 75±0. 97) d、(4. 60±0. 86) d、(4. 52±0. 73) d],差异具有统计学意义(P<0. 05)。结论早期生大黄联合肠内营养治疗SAP是有效、安全的治疗方法。

Objective To investigate the clinical effect of Dahuang (Radix et Rhizoma Rhei)combined with enteral nutrition for severe acute p ancreatitis (SAP)in early stage.Methods A total of 45patients with SAP who received treatment from January 2014to December 2017were divided into observation group (n =25)and control group (n =20). The observation group received perfusion of Dahuang and enteral nutrition solution through enteral nutrition tube,and the control group was treated by enteral nutrition tube perfusion of Dahuang.The time of relieving abdominal pain and distention,the time of recovery of gastrointestinal function and biochemical indices (such as hemodiastase)reactions were compared between two groups.Results Compared with control group,the level of hemodiastase,blood glucose and C-reactive protein (CRP)were significant lower and level of serum calcium was significant higher in observation group after one week of treatment (all P <0.05).The time of relieving abdominal pain and distention and the time of gastrointestinal function recovery in observation group were significant shorter than those in control group [(3.25±0.42)d vs (4.75±0.97)d,(3.35±0.53)d vs (4.60±0.86)d,(3.10±0.45)d vs (4.52±0.73)d,all P <0.05].Conclusion Dahuang combined with enteral nutrition in the treatment of SAP is an effective and safe treatment method.