腺垂体功能减退症患者的药学监护

Pharmaceutical care for patients with hypopituitarism

目的探讨腺垂体功能减退症患者的药学监护内容和模式。方法以腺垂体功能减退症患者1例为研究对象,对其靶腺激素补充顺序及激素不良反应实施全程化药学监护。结果对本例腺垂体功能减退症患者进行药学监护,患者入院时全身乏力,伴恶心、呕吐,给予糖皮质激素氢化泼尼松,静脉滴注第4天清晨出现躁狂、幻视症状等精神异常表现,临床药师建议更改激素治疗方案,后停用糖皮质激素,给予地西泮肌肉注射后症状好转,不良反应消失。结论临床药师积极参与腺垂体功能减退症患者的药学监护,能提高患者的用药安全性和合理性,从而提高治疗效果。

Objective To explore the content and mode of pharmaceutical care in patients with hypopituitarism. Methods In one patient with hypopituitarism as study object,the sequence of target hormone supplementation and adverse drug reactions were monitored by whole-course pharmaceutical care. Results Pharmaceutical care was given to this patient admitted to hospital with general fatigue,nausea and vomiting. In the morning of the 4 th day after intravenous drip of glucocorticoid hydrocortisone,mental disorders such as mania and hallucination symptoms,etc. appeared. The clinical pharmacist suggested that the hormone therapy should be changed. The symptoms were improved after intramuscular injection of diazepam replaceing glucocorticoid hormone,and the side effects disappeared. Conclusion The pharmaceutical care by clinical pharmacists actively for patients with hypopituitarism can improve the safety and rationality of drug use,and thus increase the therapeutic effect.