深圳市宝安区健康妊娠妇女血糖、血脂项目参考区间的建立

Establishment of reference interval of blood glucose and blood lipid items for healthy pregnant women in Baoan District,Shenzhen

目的探讨深圳市宝安区健康妊娠妇女血糖、血脂指标的变化并建立正常妊娠女性的参考区间。方法选取2017年11月-2018年8月间宝安区妇幼保健院接收的孕4~40周健康妊娠妇女1200例为研究对象,根据年龄、孕期差异分组,每组150例,均行血糖、血脂指标检测,建立深圳市宝安区健康妊娠妇女血糖、血脂指标的参考区间。结果与19~32岁组孕妇比较,33~45岁组孕妇血清FPG、TG、Apo B水平较显著升高,血清HDL、Apo A水平显著降低,差异有统计学意义(P <0. 05),而不同年龄段孕妇TC、LDL水平间差异无统计学意义(P> 0. 05);不同孕期孕妇血糖、血脂指标间差异均有统计学意义(P <0. 05),其中,血清FPG水平孕早期最高,孕中期达最低值,后随孕周延长而升高;血清TC、TG、Apo A、Apo B水平随孕周延长而升高;血清HDL水平随孕周延长而升高,至晚孕期达最高,产前期略有下降;而血清LDL水平并未表现出与孕期的相关性。结论不同年龄、不同孕期健康妊娠妇女血糖、血脂指标间存在差异,初步建立不同年龄、不同孕期健康妊娠妇女血糖、血脂指标的参考区间。

Objective To explore the changes of blood glucose and blood lipid items of healthy pregnant women in Baoan District of Shenzhen,and to establish the reference interval of normal pregnant women.Methods 1200 cases healthy pregnant women from 4 to 40 pregnancy weeks were recruited by the Baoan District maternal and child health care hospital from November 2017 to August 2018.They were grouped according to their age and gestational weeks,and 150 cases were in each group.The blood glucose and blood lipid items were detected to establish the reference range of blood glucose and blood lipid items of healthy pregnant women in Baoan District of Shenzhen.Results Compared with the 19-32 years old group,the serum levels of FPG,TG and ApoB increased significantly,and the levels of HDL and ApoA significantly decreased in the 33-45 years old group (P<0.05).There were no significant differences in TC and LDL levels between different age groups (P>0.05).There were significant differences in blood sugar and blood lipid indexes between different gestational weeks (P<0.05).Among them,the level of serum FPG was the highest in the early pregnancy,the lowest in second trimester of pregnancy,and then increased with the prolongation of the gestational weeks.The levels of serum TC,TG,ApoA and ApoB increased with the prolongation of gestational weeks.The level of serum HDL increased with gestational age,reached the highest level in the third trimester of pregnancy and decreased slightly before delivery.The serum LDL level did not show a correlation with gestational age.Conclusion There are differences in blood sugar and blood lipid among healthy pregnant women with different ages and gestational weeks.The reference interval of blood glucose and blood lipid indexes of healthy pregnant women with different age and gestational weeks was initially established.