康复愈瘫汤加减联合血栓通注射液治疗脑梗死后遗症临床观察

Clinical Observation on Modified Kangfu Yutan Tang Combined with Xueshuantong Injection for Sequelae of Cerebral Infarction

目的:探究康复愈瘫汤加减联合血栓通注射液对脑梗死后遗症患者神经功能及日常生活能力的影响。方法:将脑梗死后遗症患者96例分为2组各48例。2组均给予常规治疗,对照组给予血栓通注射液治疗,观察组采取血栓通注射液联合康复愈瘫汤加减治疗,2组均持续治疗1月。比较2组治疗前后神经功能缺损评分(NIHSS)、日常生活能力评分(BI)与血液流变学指标:血浆黏度、纤维蛋白原(FIB)、红细胞压积(HCT)水平,统计2组总有效率、不良反应发生率。结果:观察组总有效率91.67%,高于对照组的70.83%,经秩和检验,差异有统计学意义(P <0.05)。治疗1月后观察组NIHSS评分较对照组降低,BI评分较对照组高,差异有统计学意义(P <0.05)。观察组治疗1月后血浆黏度、FIB、HCT水平均较对照组降低,差异有统计学意义(P <0.05)。不良反应组间对比,差异无统计学意义(χ~2=0.261,P> 0.05)。结论:康复愈瘫汤加减联合血栓通注射液治疗脑梗死后遗症患者疗效显著,可明显改善其血液流变学状况,缓解其神经功能损伤症状,提高其日常生活能力,且具有较高安全性。

Objective:To explore the effect of modified Kangfu Yutan tang combined with Xueshuantong injection on the nerve function and the activity of daily life of patients with sequelae of cerebral infarction. Methods:Divided 96 cases of patients with sequelae of cerebral infarction into two groups randomly, 48 cases in each group. The two groups received routine treatment. The control group additionally received Xueshuantong injection for treatment, while the observation group additionally received Xueshuantong injection combined with modified Kangfu Yutan tang. The two groups were treated for one month continuously. Compared the scores of national institutes of health stroke scale(NIHSS),Barthel index(BI) and levels of hemorheology indexes including plasma viscosity,fibrinogen(FIB) and hematocrit(HCT) before and after treatment,and calculated the total effective rate and the incidence of adverse reactions of the two groups. Results:The total effective rate was 91.67% in the observation group,higher than that of 70.83% in the control group,the difference being significant(P<0.05). After one month of treatment,the NIHSS score in the observation was lower than that in the control group,while the BI score was higher than that in the control group,the difference being significant(P < 0.05). After one month of treatment,levels of plasma viscosity,FIB and HCT in the observation were lower than those in the control group,the difference being significant(P<0.05). No significant difference was found in the comparison of the incidence of adverse reactions between the two groups (χ^2=0.261,P>0.05). Conclusion: The therapy of modified Kangfu Yutan tang combined with Xueshuantong injection has significant effect in treating patients with sequelae of cerebral infarction,which can effectively improve the hemorheology indexes,relieve the injury of neural function and improve the activity of daily life with high safety.