中药通窍活血汤联合脑蛋白水解物对老年痴呆患者日常生活能力和血清Hcy、CRP、FA水平的影响

Effect of Tongqiaohuoxue Decoction Combined with Brain Protein Hydrolysate on the Ability of Daily Life and Serum Hcy, CRP and FA Levels of Senile Patients with Dementia

目的:探讨中药通窍活血汤联合脑蛋白水解物对老年痴呆日常生活能力和血清同型半胱氨酸(Hcy)、C反应蛋白(CRP)、叶酸(FA)水平的影响。方法:选择2014年1月～2016年12月在我院脑病科神经内科进行诊治的79例老年痴呆患者,随机分为对照组40例和观察组39例。对照组静脉滴注脑蛋白水解物治疗,每次60 mg,每天2次;观察组联合口服中药通窍活血汤治疗,每天服用1剂,早晚分2次温服,每次200 mL。分别于治疗前后采用简易精神状态检查量表(MMSE)对患者的精神状态进行评估,比较两组的临床治疗有效率,治疗前后的日常生活能力情况以及血清Hcy、CRP、FA水平的变化,比较两组在治疗期间不良反应的发生情况。结果:观察组的有效率为92.31%(36/39),明显高于对照组的72.50%(29/40)(P<0.05)。两组治疗后的日常生活能力BI、MMSE评分、血清FA水平均较治疗前明显升高(P<0.05),且观察组明显高于对照组(P<0.05)。两组治疗后的血清Hcy、CRP水平均较治疗前明显降低(P<0.05),且观察组明显低于对照组(P<0.05)。两组不良反应的发生情况间比较无显著差异(P>0.05)。结论:中药通窍活血汤联合脑蛋白水解物对老年痴呆患者具有较为显著的临床效果,安全可靠,可提高其日常生活能力,改善精神状态以及血清Hcy、CRP、FA水平。

Objective: To investigate the clinical effect of Tongqiaohuoxue decoction combined with brain protein hydrolysate on the ability of daily life and serum Hcy, CRP and FA levels of senile patients with dementia. Methods: 79 cases of senile patients with dementia who were treated in our hospital from January 2014 to December 2016 were selected and randomly divided into two groups. The control group was treated with intravenous infusion of brain protein hydrolysate, 60 mg each time, 2 times a day. The observation group was combined with Tongqiaohuoxue decoction treatment. The mental state of patients was evaluated by mini mental state examination (MMSE) before and after treatment. The clinical effective rate, daily living ability and serum Hcy, CRP and FA levels of the two groups were compared before and after treatment. The incidence of adverse reactions in the two groups was compared between the two groups. Results: After treatment, the effective rate of observation group was 92.31%(36/39), which was significantly higher than that of the control group [72.50%(29/40)](P<0.05); the BI score of daily living ability, score, mental state MMSE score and serum FA level of both groups were significantly increased (P<0.05), which were significantly higher in the observation group than those of the control group (P<0.05); while the levels of serum Hcy and CRP of both groups were significantly decreased (P<0.05), which were significantly lower in the observation group (P<0.05). There was no significant difference in the adverse reactions between the two groups (P>0.05). Conclusions: Tongqiaohuoxue decoction combined with brain protein hydrolysate had more significant clinical effect on the senile dementia patients with high safety, it could improve the ability of daily life, mental state and serum Hcy, CRP, FA levels.