百令胶囊辅助治疗哮喘-慢性阻塞性肺疾病重叠患者疗效观察

Clinical Efficacy of Bailing Capsule for Patients with Asthma-COPD Overlap

目的:观察百令胶囊辅助治疗哮喘-慢性阻塞性肺疾病重叠(ACO)患者的临床疗效。方法:61例ACO门诊患者随机分为对照组30例和观察组31例。对照组给予常规治疗;观察组在对照组治疗基础上加用百令胶囊,比较两组患者随访1年后的急性加重次数及稳定期持续时间,以及治疗前后两组肺功能(FEV1%pred、FEV1/FVC、PEF日变异率)、诱导痰炎细胞分类和比例、血清炎症因子(IL-4、IL-6、TNF-α)水平、SGRQ评分和6 min步行距离(6 MWD)等指标等变化。结果:观察组随访1年后急性加重次数明显低于对照组,稳定期持续时间明显高于对照组(P <0. 05)。观察组治疗后PEF日变异率较前降低(P <0. 05)。治疗后两组诱导痰中性粒细胞和嗜酸性粒细胞比例降低,巨噬细胞比例升高(P <0. 01),且观察组中性粒细胞和嗜酸性粒细胞比例低于对照组,巨噬细胞比例高于对照组(P <0. 05)。两组治疗后血IL-4、IL-6、TNF-α均较治疗前下降(P <0. 05),SGRQ评分降低,6MWD值升高(P <0. 05);两组间比较差异无统计学意义(P> 0. 05)。结论:百令胶囊用于辅助治疗ACO可以改善患者的临床指标,提高生活质量。

Objective: To explore the clinical efficacy of bailing capsule for treating patients with asthma-COPD overlap( ACO). Methods: 61 patients with ACO were collected in the respiratory department and randomly divided into control group( 30 cases) and observation group( 31 cases). While the control group was given conventional treatment,the observation group was given bailing capsule on the basis of conventional treatment,comparing the acute exacerbation frequency and steady duration,pulmonary ventilation function such as FEV1% Pred,FEV1/FVC,diurnal PEF variability,classification and proportion of sputum-induced inflammatory cells,the level of IL-6,IL-4,TNF-α in blood serum,SGRQ scores and 6 minutes walking distance( 6 MWD). Results: After one year of follow-up,compared with the control group,the acute exacerbation frequency of the observation group decreased significantly,and the steady duration increased significantly( P < 0. 05); diurnal PEF variability of the observation group decreased after treatment than before( P < 0. 05). After treatment,the neutrophils and eosinophils of sputum-induced decreased,macrophages increased in both two groups( P< 0. 05); Compared with the control group,the neutrophils and eosinophils were lower and the macrophages were much higher than the observation group( P < 0. 05); The IL-4,IL-6 and TNF-α in both groups decreased after treatment( P <0. 05),SGRQ scores decreased and the 6 MWD increased after treatment( P < 0. 05). There was no difference between two groups( P > 0. 05). Conclusion: Bailing capsule could improve the clinical indexes and the quality of life of patients with ACO as an adjuvant therapy.