34例儿童未成熟性畸胎瘤临床病理分析

Clinicopathologic analysis of 35 cases with immature teratoma

目的探讨儿童未成熟性畸胎瘤的临床病理特点。方法对昆明市儿童医院34例儿童畸胎瘤的临床资料,病理类型及治疗和预后等进行回顾性分析。结果患儿年龄为17d^7岁,平均年龄为1岁1月,男性22例,女性12例,男女之比1.8∶1,病理分级1级14例,2级10例,3级10例。所有患儿均经手术切除,20例术后加做化疗,14例未做化疗,有24例无瘤存活,5例死亡,其中4例为病理分级3级,未加做化疗,1例为2级单纯手术切除后复发并死亡,5例失访。结论未成熟性畸胎瘤的确诊主要依靠病理形态学,病理分级及治疗方法对患儿预后具有重要意义。

Objective To investigate the clinical and pathological features of immature teratoma in children. Methods The clinical data,pathological types,treatment and prognosis of 34 children with immature teratoma in Kunming Children's Hospital were retrospectively analyzed. Results The patient's age was 17 days - 7 years,and the average age was 13 months,including 22 males and 12females,with the male /female ratio of 1.8∶1. Histologically,14 cases were of grade 1,10 cases of grade 2 and 10 cases of grade 3.All patients accepted surgery,of whom 20 cases were treated with chemotherapy and 14 cases were not treated with chemotherapy.24 cases obtained complete remission and 5 cases died. 4 cases(grade 3) of them did not undergo chemotherapy.1 case of grade 2 occurred recurrence after surgery and died. 5 cases lost follow - up.Conclusion The diagnosis of immature teratoma mainly depends on pathological morphology,so pathological grading and treatment methods have important significance to patients' prognosis.