男性脱发与前列腺癌发病风险的相关性:一项系统回顾和荟萃分析

Male pattern baldness and risk of prostate cancer:a systematic review and meta-analysis

目的:通过开展基于既往相关队列研究和病例对照研究的荟萃分析,研究男性脱发与前列腺癌发病风险的相关性。方法:文献检索自PubMed、Web of Science和中国知网数据库,检索截止时间为2017年5月30日。DerSimonian-Laird随机效应模型被用于计算合并后的RR和95%CI。结果:本项荟萃分析共纳入15项研究。在总体分析中,男性脱发(任何类型)与前列腺癌发病风险之间无相关性(RR=1.03,95%CI:0.96～1.11)。纳入研究之间存在显著的异质性(P=0.078,I^2=36.4%)。对脱发类型进行亚组分析,发现头顶脱发和前列腺癌发病风险显著相关(RR=1.24,95%CI:1.05～1.46),而其他类型的脱发则无相关性。结论:头顶脱发的男性可能具有较高的前列腺癌发病风险,但由于总体分析以及大多数的亚组分析结果阴性,并且研究之间存在一定的异质性,本研究结果还需进一步设计良好的前瞻性队列研究来验证。

Objective:The relationship between male pattern baldness and incidence of prostate cancer is still inconclusive.Hence we performed the present meta-analysis based on eligible relevant cohort and case-control studies.Method:A comprehensive literature search was performed in May 2017 based on PubMed,Web and CNKI of Science databases.Pooled RR and its 95% CI was calculated with a DerSimonian and Laird randomeffects model.Result:Finally,a total of 15 studies were included in this meta-analysis.Overall,no statistically significant association between baldness(any pattern)and prostate cancer risk was identified(RR=1.03,95%CI:0.96-1.11).There was obvious heterogeneity across included studies(P=0.078 for heterogeneity,I^2=36.4%).When subgroup analysis by types of baldness,statistically significant association was observed for vertex baldness(RR=1.24,95%CI:1.05-1.46)but not for other types of baldness.Conclusion:Individuals with vertex baldness may have an increased risk of prostate cancer.Given the obvious heterogeneity and null results in overall analysis and most of subgroup analyses,further large well-designed prospective cohort studies are warranted to confirm our preliminary findings.