妊娠中期羊水过少的病因学研究进展

Etiology of second-trimester oligohydramnios:a review

妊娠中期羊水过少可由多种因素引起,往往导致不良结局。近年来,随着临床检测技术水平的提高,妊娠中期羊水过少的病因学研究取得了一定进展,发现了一些与妊娠中期羊水过少相关的遗传病。导致妊娠中期羊水过少的原因除胎儿畸形、胎儿生长受限、胎盘及脐带因素、母体因素和药物因素以外,应警惕常染色体隐性遗传病——肾小管发育不全。明确羊水过少的病因,有助于避免出生缺陷,也可为指导再次妊娠提供更有力的依据。由于妊娠中期羊水过少病因复杂,应结合临床、病理、遗传学等多方面证据,开展进一步研究。

The second-trimester oligohydramnios can be caused by various factors.Oligohydramnios is associated with adverse pregnancy outcomes.With the development of clinical detection,there was some progress on investigation of the etiology of second-trimester oligohydramnios.Some inheritable diseases associated with oligohydramnios were discovered.Second-trimester oligohydramnios is associated with fetal abnormalities,fetal growth restriction,and fetal,umbilical cord,maternal,or drug factors.Besides them,renal tubular dysgenesis,an autosomal recessive disorder,might be another associated factor of second-trimester oligohydramnios.Birth defects can be avoided by clarifying the etiology of second-trimester oligohydramnios, and the instruction for further pregnancies.Since the etiology of second-trimester oligohydramnios is still unclear,more clinical,pathological and genetic researches are needed.