益生菌联合美沙拉嗪对溃疡性结肠炎远期疗效的临床研究

Long-term efficacy of probiotics on ulcerative colitis

目的探究益生菌联合美沙拉嗪在治疗溃疡性结肠炎(UC)中的远期疗效。方法选取2016年1月—2017年1月渭南市中心医院确诊并进行治疗的96例UC患者,按照随机数字表法将其均分为观察组和对照组,每组48例,其中对照组患者使用美沙拉嗪进行治疗,观察组在对照组基础上加用益生菌进行治疗,治疗前后测定两组血清肿瘤坏死因子-α(TNF-α)、白细胞介素1β(IL-1β)及C反应蛋白(CRP)水平,对比两组治疗有效率,治疗第3、6个月对两组进行随访,对比复发率,第6个月测定两组血红蛋白、红细胞压积及白蛋白水平。结果两组治疗前TNF-α、IL-1β及CRP水平无明显差异,与治疗前对比,治疗后两组TNF-α、IL-1β及CRP水平出现显著下降(P<0.05),同时观察组TNF-α、IL-1β及CRP水平较对照组低,差异具有统计学意义(P<0.05)。观察组治疗有效率为93.75%,对照组为83.33%,差异具有统计学意义(P<0.05)。3个月随访观察组复发率为2.08%,对照组为8.33%;6个月随访观察组复发率为6.25%,低于对照组的18.75%,差异均具有统计学意义(P<0.05)。观察组血红蛋白、红细胞压积及白蛋白水平显著升高,而对照组则无显著变化,差异具有统计学意义(P<0.05)。结论使用益生菌联合美沙拉嗪对UC进行治疗的方式切实有效,不仅能够提高治疗有效率,还能够改变其血清内炎症因子的含量,同时降低远期复发率,效果值得肯定,值得进行临床推广。

Objective To explore the long-term efficacy of probiotics in the treatment of ulcerative colitis (UC).Methods A total of 96 UC patients diagnosed and treated in our hospital from January 2016 to January 2017 were randomly divided into experimental group and control group, with 48 cases in each group. The control group patients The experimental group was treated with probiotics on the basis of the control group. The levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and C-reactive protein CRP levels were compared between the two groups. The third month and the sixth month of treatment were followed up, the relapse rate was compared, and the hemoglobin, hematocrit and albumin level were measured at the sixth month. Results There was no significant difference in the levels of TNF-α, IL-1β and CRP between the two groups before treatment. Compared with those before treatment, the levels of TNF-α, IL- The levels of TNF-α, IL-1β and CRP in the experimental group were significantly lower than those in the control group (P<0.05). The effective rate was 93.75% in the experimental group and 83.33% in the control group, with significant difference (P<0.05). The recurrence rate was 2.08% in the experimental group and 8.33% in the control group at 3 months of follow-up. The recurrence rate in the 6-month follow-up group was 6.25%, which was lower than that in the control group (18.75%, P<0.05). The levels of hemoglobin, hematocrit and albumin in the experimental group were significantly increased, while those in the control group showed no significant difference (P<0.05).Conclusions The probable treatment of UC with probiotics is effective and effective. It can not only improve the therapeutic efficiency, but also change the content of inflammatory cytokines in the serum, and reduce the long-term recurrence rate. The effect is worthy of clinical promotion.